Effect of Citicoline on PD

Citicoline is a nucleoside derivative that can be hydrolyzed to produce cytidine and choline. As an important coenzyme for the synthesis of phosphatidylcholine, when the central nervous system is damaged, it can protect the nerves by participating in regeneration and repair.

As an activator of human metabolism, citicoline is also an important coenzyme for the synthesis of lecithin. It can reach brain tissue through the blood-brain barrier, and can combine with membrane phospholipids in brain cells to increase blood flow in the brain, thereby increasing the metabolic function of nerve cells.

In addition, citicoline can increase the activity of mitochondrial ATPase and membrane Na + -K + -ATPase, stabilize the nerve cell membrane and ensure the integrity of neuron synapse structure, and reduce the apoptosis of nerve cells.

Parkinson's disease has a high incidence in middle-aged and elderly people, and the lack of awareness of its non-motor symptoms leads to the gradual aggravation of the disease. Therefore, early screening of patients' cognitive function and neurological function and treatment for the symptoms are of great significance to prevent the progression of the disease. Adjuvant citicoline therapy in patients with Parkinson's can effectively improve the neurocognitive function of patients.

Citicoline can be hydrolyzed to produce choline and cytidine, and choline is an important coenzyme in the process of lecithin synthesis. Lecithin is an important component of cell membranes. When choline is acetylated into acetylcholine, the synthesis of the neurotransmitter acetylcholine in the cell will increase, and the integrity of the central nervous system function will be well protected by exciting the cholinergic nerve, thereby enhancing the function of the cerebral cortex and reducing nerve function. Cognitive impairment.

In addition, as a nucleoside derivative, citicoline can reduce vascular resistance to a certain extent, increase cerebral blood flow, improve microcirculation, and promote brain substance metabolism. Citicoline can be hydrolyzed into cytidine and choline, and can enter the central nervous system through the blood-brain barrier to repair damaged nerves. Can produce good bioavailability in organic disease. Adjuvant citicoline therapy for Parkinson's patients can improve the therapeutic effect, improve their neurocognitive function and have less adverse reactions.

Tag: Citicoline , PD

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