NMN and nervous system improvement

The human brain is composed of numerous neural networks, each area has its own unique function, and the decline of brain function actually begins in the twenties and thirties, and the common Alzheimer's disease is a degenerative disease of the nervous system.

It is a consensus in the academic community that the reduction of NAD+ is a key trigger of age-related functional decline in many tissues and organs. The hypothalamus, a high-level center under the cerebral cortex that regulates visceral and endocrine activities, has also been proven in many studies to be the high-level control center of aging in mammals.

The hypothalamus controls fluid and electrolyte balance, food intake and energy balance, reproduction, thermoregulation, immunity, and various emotional responses through autonomic and endocrine effector systems.

Studies have shown that in two subregions within the hypothalamus, the dorsal and lateral hypothalamic nuclei, the NAD+-dependent protein deacetylase Sirt1 and the homeodomain transcription factor Nkx2-1 cooperate to regulate the expression of key genes and promote neuronal development. activity to delay aging in mice.

On January 25, 2023, a research team from the Kobe Institute of Biomedical Research in Japan, the Tokyo Institute of Aging Research, and the University of Washington School of Medicine published a research report in "NPJ Aging" showing that supplementing NMN may restore the hypothalamic arch in aged mice. The NAD+ levels in the nucleus, ventromedial hypothalamus, and lateral hypothalamus reached young levels, further indicating that NMN supplementation may be an effective way to fight aging.

The researchers compared local NAD+ changes in the hypothalamic nuclei of 3-month-old mice (equivalent to 20 years old in humans) and 22-month-old mice (equivalent to 60 years old in humans) and found that the arcuate hypothalamic nuclei in 22-month-old mice NAD+ levels in the nucleus, ventromedial hypothalamus and lateral hypothalamus were significantly lower than in 3-month-old mice.

After supplementing NMN to aged mice, it was found that the NAD+ levels in the arcuate nucleus of the hypothalamus (ARC), ventromedial hypothalamus (VMH), lateral hypothalamus (LH) and dorsomedial hypothalamus (DMH) of aged mice decreased. There is a significant improvement.

(Picture note: Experiments show that NMN increases the NAD+ level in the hypothalamus of aged mice)

We look forward to more experimental and human trial results of NMN on the nervous system to help us improve various problems caused by brain aging.

Tag: NMN

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