NMN can improve myocardial infarction

Myocardial infarction is a common heart disease, which is myocardial necrosis caused by acute and persistent coronary ischemia and hypoxia. The onset of this heart disease, which leads to the death of heart muscle cells, is one of the causes. Although rapid restoration of blood flow and reperfusion is the main measure in the treatment of myocardial infarction, myocardial cells that are ischemic for a specific period of time may suffer progressive damage or even death when their blood supply is restored.

NMN (Nicotinamide Mononucleotide) is an important coenzyme that is considered to have potential in improving myocardial infarction and promoting recovery of cardiac function. Research shows that vesicles secreted by NMN-treated stem cells (referred to as NVs) may become a new method for treating myocardial infarction. These N-Vs vesicles not only improved cardiac function after myocardial infarction in rats, but also promoted blood vessel formation and reduced tissue damage. Therefore, NMN has potential therapeutic value in promoting stem cell vesicles to repair cardiac damage.

In 2023, a study published by Nanjing Medical University in "Stem Cell Reviews and Reports" proved that NMN can improve myocardial infarction and promote angiogenesis. Mesenchymal stem cell-derived extracellular vesicles are cardioprotective in acute myocardial infarction. In a rat model of heart disease, NMN improved cardiac function, increased vascularization, and reduced tissue damage by modulating hepatocyte-derived vesicles.

Recent research has shown that stem cells (mesenchymal stem cells) secrete membrane-bound sacs called extracellular vesicles that are filled with potential therapeutic molecules. Like stem cells, these vesicles have therapeutic properties. They also have advantages over stem cells, including a lack of immune system rejection and tumor induction. When subjected to various stimuli, the vesicle content of stem cells changes, thereby affecting their biological effects.

Researchers used surgery to induce coronary artery occlusion in rats, causing heart tissue damage and simulating a heart attack. They then injected untreated stem cell vesicles and NMN-treated stem cell vesicles at the edge of tissue damage in rats. After four weeks, they found that the untreated vesicles increased left ventricular ejection fraction — the fraction of blood the heart pumps out. In addition, N-Vs further improved ejection fraction, indicating enhanced cardiac function repair.

After a heart attack (MI), the left ventricular ejection fraction (EF) % is lower than normal (Sham). Stem cell-derived vesicles (m-ev) increase the ejection fraction, indicating improved heart function. When stem cells first The ejection fraction was further increased upon subsequent treatment with NMN (n-ev).

The pumping action of the heart is most efficient when the blood flow regulated by the blood vessels is optimal. The researchers found that untreated stem cell vesicles increased the density of arterioles and capillaries in heart tissue from rats after a heart attack. In addition, N-Vs further increased arterial and capillary density. These findings suggest that NMN promotes vesicle-mediated angiogenesis, thereby increasing blood flow.

Compared with normal (Sham), myocardial infarction (MI) does not significantly increase the formation of arterioles (left) and capillaries (right); while stem cell vesicles (m-ev) significantly increase blood vessel formation, when stem cells first Blood vessel formation was further enhanced when regulated by NMN (n-ev).

In this regard, researchers from the First Affiliated Hospital of Nanjing Medical University, China, said: "Our research shows that extracellular vesicles of stem cells can promote blood vessel formation, promote proliferation, inhibit apoptosis, reduce fibrosis and improve cardiac function. to improve cardiac function, and these functions are further enhanced after NMN treatment."

Tag: NMN

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