NMN exhibits positive ameliorating effects on eye aging

NMN improves vision, the efficacy and effect of nmn on the eyes, in February 2021, Li Xinyu, director of the Department of Ophthalmology, Tongji Hospital Affiliated to Huazhong University of Science and Technology, published an article in the academic journal "J Inflamm Res", saying that NMN can reduce dry eye syndrome caused by tear hyperosmolarity in the early stage. Corneal inflammatory damage, to avoid further deterioration of dry eye disease. This study established an in vitro model of hyperosmotic stress based on sodium chloride, and used it in a co-culture system of corneal epithelial cells and macrophages to explore the effect of NMN on NAD+ metabolism and hyperosmotic stress in corneal epithelial cells Effects of biomarker expression. The results showed that after 24 hours of hyperosmotic stress treatment, the cell viability decreased significantly, while after 12 hours of NMN treatment, the cell viability increased significantly.

NMN improves vision, the efficacy and effect of nmn on the eyes, in view of corneal epithelial cell apoptosis plays a key role in the occurrence and development of dry eye disease, this study also detected the biological role of NMN in cell apoptosis, flow cytometry detection found that NMN treatment could slow down the total apoptosis induced by hyperosmotic stress. Studies have shown that the cytokine IL-17a is involved in the pathological process of eye diseases and plays an important role in the pathogenesis of dry eye disease. Therefore, this study further tested the effect of NMN treatment on the expression of IL-17a, and the results showed that the expression of IL-17a gene in hyperosmotic stress group cells was increased, and NMN could inhibit the expression of IL-17a through SIRT1. Preliminary conclusions show that NMN can alleviate hyperosmotic stress-induced dry eye disease by regulating the interaction between corneal epithelial cells, and it is expected to become an effective drug for the prevention and treatment of dry eye disease.

The researchers further explored the reasons behind it and found that NMN increased NAD+ levels, and NAD+ activated the longevity protein SIRT1, which is essential for retinal development and survival.

Previous studies have shown that altered SIRT1 activity is found in aged retina, diabetic retinopathy, light-induced retinal degeneration, and oxygen-induced ischemic retinopathy (OIR). This means that NMN may have a positive effect on these eye problems.

By improving mitochondrial function and activating SIRT1, NMN exhibits positive ameliorating effects on eye aging:

1. Improve lacrimal gland function

2. Reduce spots under the eyes

3. Improve retinal mitochondrial function

4. Improve macular degeneration

5. Inhibit the progression of retinal detachment

6. Inhibit retinal inflammation and reduce oxidative stress

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