NMN guide most complete

NMN, as the star of anti-aging supplements, is favored both in the scientific research field and the consumer market.

Every year, a large number of NMN anti-aging studies are published in internationally renowned journals, showing a multi-faceted improvement effect.

According to the "Global and Chinese anti-aging Industry Development and Consumer Demand Research Report 2022-2023" released by iMedia Consulting, consumers surveyed spend more on NMN supplements than anti-aging skin care products.

As more and more attention has been paid to NMN, questions about it have naturally increased:

Is NMN secure? Is it effective? How should I eat it?

1. Can NMN really resist aging?

Since Professor David Sinclair discovered in 2013 that NMN can extend the life span of mice, NMN, known as the "elixir", has been widely favored by academics and consumers.

To date, hundreds of NMN research papers have been published in international academic journals:

NMN has been shown to delay aging and prevent and delay a variety of age-related diseases:

It can help delay the aging of the body organs, improve the aging of the female ovary and the spermatogenic function of the male, delay the aging of the brain and nervous system, and improve the intestinal flora, high blood sugar and cardiovascular problems.

At present, human clinical results have confirmed that NMN can effectively improve insulin sensitivity, enhance immunity, delay arteriosclerosis, muscle atrophy, skin aging, intestinal aging...

2. Does NMN have side effects?

No side effects. At present, NMN has published more than a dozen clinical research results, the participants are male and female, there are healthy people and basic diseases (such as pre-diabetes) people, from the age of 20 to 70 years old, the dosage from 100mg to 2000mg/ day, no toxicity and side effects were found.

3. Is there dependence on eating NMN?

NMN is an endogenous substance in the human body, and many foods also contain trace amounts of NMN, and there is no physiological dependence on taking NMN. No dependence has been found in all clinical studies and animal experiments.

4. What is the optimal dose of NMN?

At present, the maximum dosage shown to be safe in human clinical practice is about 1200mg/ day.

However, NMN is not the more you eat the better the effect, comprehensive human clinical point of view, 600mg/ day on the human body gain the best effect.

In addition to dose, supplement brand, individual absorption should also be considered.

5. Eating NMN is said to cause cancer? Oh, really?

There are currently no reproducible, accepted studies proving that NMN causes cancer.

The idea that NMN causes cancer stems from a study published by the University of Pennsylvania in 2019, which found that NMN promoted the increase of diseased areas in mice with cancer, and concluded that "NMN may accelerate the further deterioration of cancerous tissues."

But three years later, similar experiments have failed to produce any reproducible results. On the contrary, in 2021, Zhu Junjie et al., Affiliated Pulmonary Hospital of Tongji University, also injected NMN into mice with cancer and found that NMN had no effect on the lesion area.

6. Can NMN be taken with other supplements?

Agreed. However, there are a wide variety of dietary supplements on the market, and if you do not understand the mechanism of action, you can eat half an hour apart.

NMN combined with resveratrol, ginsenosides and proanthocyanidins can improve the level of NMN and NAD+.

NMN, in combination with methyl donors such as betaine and methylfolate, can mitigate the health risks caused by large methyl consumption (NAM, a metabolite of NAD+, consumes large amounts of methyl).

7. When to eat NMN effect is good?

The effect of eating NMN at noon is good, and the metabolism level of NAD+ in cells and SIRT1 activity will reach the peak at noon every day. When taken at this time, the utilization rate of NAD+ in cells will be maximized.

Taking at night will weaken the effect by more than half, eating in the morning is not effective, and even the elderly will have a reverse effect.

8. Which foods are rich in NMN?

Broccoli (0.25-1.12mg/100g food), cucumber peel (0.65mg/100g food), edamame (0.47-1.88mg/100g food), avocado (0.36-1.6mg/100g food)

Since the content of NMN in food is very small, it seems impossible to ingest enough NMN and achieve anti-aging effects through "dietary supplements".

9. How long can eat NMN have effect?

The effect of NMN is related to factors such as product and individual physique. At present, the NMN products on the market are uneven, and the quality and content of raw materials are different.

An October ChromaDex analysis of Amazon's 22 top-selling NMN brands found that more than 64% of them contained little to no NMN.

Secondly, the mechanism is effective, clinical results are not the same as everyone has obvious body feeling, any supplement is not a "master key".

10. Who needs to take NMN?

NMN is safe and widely adaptable, and in general, it can be tried over the age of 25, and the dosage can be appropriately increased over the age of 35 or 40.

Note that the following groups are not suitable for eating:

(1). High NAD+ level in minors, no need to supplement;

(2). Not recommended for pregnant and lactating women;

(3). People with high uric acid are recommended to start with a small amount of caution, such as in the period of gout attacks, it is recommended to stop taking;

(4). Patients with tumors or multiple cysts, people suffering from mental illness, people suffering from allergic diseases, and other serious physical discomfort, please consult a doctor first.

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