NMN improves blood-brain barrier and reduces risk of stroke cognitive impairment

NMN has shown significant potential to improve blood-brain barrier (BBB) function and reduce the risk of cognitive impairment in stroke.

NMN improves blood-brain barrier function

The blood-brain barrier is a protective barrier between the brain and blood, and is essential for maintaining the stability of the brain microenvironment.

As we age, the integrity of the blood-brain barrier is compromised, leading to cognitive decline and the development of neurodegenerative diseases.

NMN improves BBB function in the following ways:

Repair blood-brain barrier damage

Studies have shown that NMN can repair the damage of blood-brain barrier caused by aging through CX43-PARP1-NAD+ signaling pathway.

This finding provides new avenues for the prevention and treatment of diseases associated with blood-brain barrier dysfunction.

Improve blood-brain barrier permeability

Long-term dietary NMN intervention can improve the permeability of the blood-brain barrier in aging mice and help maintain the normal function of the blood-brain barrier.

NMN reduces the risk of stroke cognitive impairment

Stroke is an acute cerebrovascular disease caused by a sudden rupture of a blood vessel in the brain or by a blocking ischemia.

Stroke not only has a high mortality rate, but the after-effects are also a major problem, especially in terms of cognitive impairment.

By improving blood-brain barrier function and raising NAD+ levels, NMN may reduce the risk of stroke cognitive impairment:

Reduce brain damage caused by stroke

NMN preconditioning can reduce brain injury caused by stroke, which may be related to the protective effect of NMN on the blood-brain barrier.

By maintaining the integrity of the blood-brain barrier, NMN can reduce damage to the brain from toxins and harmful substances, thereby reducing the severity of stroke.

Prevent blood-brain barrier leakage

NMN prevents age-related blood-brain barrier leakage, which is an indicator of blood-brain barrier dysfunction.

By preventing leakage of the blood-brain barrier, NMN can reduce the risk of developing diseases such as stroke and Alzheimer's disease.

Improve cognitive function after stroke

Studies have shown that NMN can improve balance and cognitive performance in mice after stroke, suggesting that NMN can counter behavioral deficits associated with brain injury and help reduce the risk of cognitive impairment after stroke.

Research support

Multiple studies have supported the role of NMN in improving the blood-brain barrier and reducing the risk of cognitive impairment in stroke.

For example, research by the Peking University team indicates that NMN has a repairing effect on age-induced blood-brain barrier damage through the CX43-PARP1-NAD+ signaling pathway and significantly reduces the volume of cerebral infarction.

These studies provide a new scientific basis for the application of NMN in the field of neuroprotection.

NMN shows significant potential to reduce the risk of stroke cognitive impairment by improving blood-brain barrier function and increasing NAD+ levels.

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