New idea of NMN weight loss

The hazards of obesity include joint soft tissue damage, decreased reproductive capacity, and psychological disorders, heart disease, diabetes, atherosclerosis, fatty liver, gallstones, edema, gout, etc.

As early as 2016, the team of Professor Shinichiro Imai at Washington University in St. Louis conducted a study that showed that mice taking NMN consumed more food than the control mice, but weighed less and had enhanced basal metabolism.

▲Mice in the NMN group consumed more and weighed less

In 2019, the "Nature" sub-journal published the research results of the Third Affiliated Hospital of Sun Yat-sen University, which confirmed the effect of NMN on fat and weight loss from the perspective of stem cells.

Mesenchymal stem cells (MSCs) have the potential of self-renewal and multidirectional differentiation, and can differentiate into a variety of mesenchymal tissues, such as bone, cartilage, fat, bone marrow and hematopoietic tissues.

The energy metabolism level of MSCs gradually becomes unstable as people age, causing the body to differentiate more fat cells. NMN can activate SIRT1, improve the metabolic imbalance of MSCs, improve the ability of osteoblasts, and reduce the differentiation of adipocytes.

▲NMN promotes the generation of osteoblasts by mesenchymal stem cells and reduces the generation of adipocytes

Newly published research confirms that NMN also helps protect against metabolic abnormalities caused by a high-fat diet (HFD). 4-week-old mice received either a normal diet (ND) or a high-fat diet (HFD) for 12 weeks, and it was found that the HFD mice gained significantly more weight than the normal-diet mice.

Next, the researchers used a control method to intraperitoneally inject NMN into some high-fat diet mice for 10 consecutive days, and found that NMN reduced the fat size of the high-fat diet mice (D).

▲normal diet (ND), high fat diet (HFD),

Adipocyte control of HFD+NMN mice

Recently, relevant human studies have shown that NMN supplementation can significantly increase the NAD+ level in the blood of overweight or obese adults. Furthermore, this increased physiological benefit has mixed results.

According to the Journal of Clinical Endocrinology and Metabolism, researchers have shown that NMN can lower total cholesterol, including "bad" LDL cholesterol, and lower blood pressure. These findings support a metabolic stabilizing role of NMN.

▲NMN for weight loss.

Compared to participants who received placebo (red),

Participants supplemented with NMN (blue) lost about 3 kg.

This series of studies shows that NMN has broad application prospects in the field of weight management.

Tag: NMN

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