Research Prospects of NMN in Obesity Treatment

Obesity is a global health problem, and its harm is far beyond our imagination. According to the World Health Organization, there are more than 2 billion overweight adults in the world, and more than 650 million of them suffer from obesity.

Obesity will not only lead to a decline in appearance, but also poses a serious threat to our physical health. Studies have found that obesity is closely related to a series of chronic diseases, and obese patients are more likely to suffer from heart disease, high blood pressure, diabetes, stroke, fatty liver and other diseases.

In order to deal with the problem of obesity, people continue to conduct research and exploration, ranging from diet and exercise, drug treatment, psychological suggestion to all kinds of weird ways, everything is included. In a recent study, the researchers found that NMN treatment enhanced lipolysis in adipocytes by measuring the glycerol concentration in cell culture medium, which may have important implications for the treatment of obesity.

NMN is a precursor of the coenzyme NAD+, which plays an important role in energy metabolism and cellular function. In a mouse experiment induced by a high-fat diet, the researchers significantly reduced the amount of subcutaneous fat in the mice and reduced the size of adipocytes in the subcutaneous fat through NMN injection.

Through analysis, the researchers found that NMN treatment increased the protein and mRNA levels of adipose triglyceride (ATGL) in 3T3-L1 adipocytes. At the same time, NMN increased SIRT1 expression and AMPK activation, and AMPK inhibitor could restore the NMN-dependent upregulation of ATGL expression, suggesting that NMN may enhance lipolysis of adipocytes by upregulating ATGL expression through SIRT1-AMPK signaling pathway.

Although the research prospects of NMN in obesity treatment are exciting, obesity is a complex problem involving multiple factors, such as diet, exercise, genetics, etc. Therefore, a single treatment plan is difficult to fundamentally solve the obesity problem. A balanced diet, regular exercise, good sleep and stress management are still the most important and effective methods. In addition, it is also worth considering to use suitable dietary supplements to assist weight loss programs.

Tag: NMN , Obesity Treatment

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