Supplementing NMN may prevent myelin aging

With age, an important manifestation of human brain decline is myelin aging. This in turn drives aging of the central nervous system (CNS), which in turn triggers neurodegenerative diseases. The mechanism behind this is related to the reduced remyelination capacity of oligodendrocyte progenitor cells (OPCs).

The authoritative research journal "Nature Communication" published about the supplementation of NMN to prevent myelin aging and promote the repair of myelin after injury, reducing the central nervous system myelin aging and demyelinating diseases such as multiple sclerosis (MS) and other autoimmunity Inflammatory diseases of the central nervous system. Supplementing NAD+ by NMN can induce SIRT2 in the mature neural stem cells-oligodendrocyte precursor cells (OPCs) in the central nervous system to enter the nucleus, and promote the differentiation of OPCs into mature oligodendrocytes (OL), eventually Delays the aging of myelin in the normal central nervous system, and enhances the remyelin regeneration of the demyelinated and aged central nervous system.

Myelin is a structure that covers the axons of neurons and has important physiological functions, such as regulating the encoding of nerve signals and providing nutritional support for axons. However, during aging, myelin undergoes characteristic structural changes, a phenomenon known as myelin aging, which is an important driver of central nervous system aging.

In the central nervous system, myelin is mainly formed by oligodendrocytes (OL). Once the OL cell body or myelin is damaged, it will cause the myelin to degenerate and detach from the axon, a condition called demyelination. However, oligodendrocyte progenitor cells (OPCs), one of the adult neural stem cells widely distributed in the central nervous system, have the potential to differentiate into mature OLs and form new myelin sheaths. The regeneration process is called remyelination.

In simple terms, demyelination is a pathological feature of the central nervous system and, therefore, represents a disease of the central nervous system to some extent. At the same time, with age, the efficiency of myelin regeneration will decrease and aging will be faster, which will also accelerate the aging process of the central nervous system.

Tag: NMN

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