Taking NMN is better for your skin than eating broccoli

A compound found in broccoli called sulforaphane slowed skin aging in mice, but the NAD+ precursor NMN (niacinamide mononucleotide) appears to be just as effective.

01 Research Background

Broccoli and other leafy greens are nutritious foods that help reduce all-cause mortality, cardiovascular disease, and cancer.

So scientists explored how sulforaphane, a key compound in leafy green vegetables, affects aging, especially skin aging.

For comparison, the researchers also measured how NMN affects skin aging.

The results suggest that NMN may be as effective or even more effective than sulforaphane in slowing skin aging.

02 NMN and sulforaphane fight skin aging

To determine the effects of sulforaphane and NMN on aging, the researchers used D-gal mice - mice that were injected with a sugar called D-galactose, which triggers accelerated aging.

D-gal mice were treated with one of three doses of sulforaphane (10 mg/kg, 30 mg/kg, or 50 mg/kg) or 100 mg/kg of NMN for eight weeks.

According to the study authors, sulforaphane treatment improved the symptoms of skin aging, including dryness, dullness, thinning and loss of elasticity.

"Partial remission of aging symptoms" was observed in the NMN group.

The researchers also measured compounds associated with skin aging, including hyaluronic acid.

They found that NMN treatment increased hyaluronic acid levels as much as the highest dose of sulforaphane.

Two potential drivers of aging are inflammation and oxidative stress - damage to cells caused by reactive oxygen species (ROS) molecules.

Therefore, inflammation and oxidative stress also contribute to skin aging.

One way to combat oxidative stress is to improve antioxidant capacity, and researchers have found that sulforaphane treatment can improve antioxidant capacity, and NMN treatment can improve antioxidant capacity even more.

Similarly, sulforaphane and NMN both reduce an inflammatory marker called IL-6.

The results of this study suggest that both sulforaphane and NMN can slow down skin aging.

By some measures, NMN appears to be as effective as sulforaphane, if not more so.

Tag: NMN

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