The four most important functions of NMN

In recent years, research on NMN (Nicotinamide Mononucleotide) has become very popular in the field of anti-aging! Many academic papers have been published in authoritative academic journals represented by Cell (Cell), Nature (Nature), and Science (Science). With the deepening of research, the anti-aging function of NMN has been discovered continuously, and more Research is ongoing.

The following are the four most important functions of NMN:

1. Activate the longevity protein SIRTUINS

Sirtuins are a family of NAD+-dependent deacetylase proteins, including Sirtuin 1 to Sirtuin 7 (SIRT 1-7). Nearly 20 years of research have found that Sirtuins play a major regulatory role in almost all cellular functions. Sirtuins affect physiological processes such as inflammation, cell growth, circadian rhythm, energy metabolism, neuronal function, and stress resistance. In 2019, Professor Kane A E of the Department of Genetics of Harvard Medical School and others found that NMN is an important precursor for the synthesis of NAD+ in vivo. ) are achieved by activating Sirtuins.

In 2019, Dr. de Picciotto N E, Department of Integrative Physiology, University of Colorado Boulder, and others found that intraperitoneal injection of NMN can increase the activity of Sirtuin1 in mouse arteries and reverse age-related arterial dysfunction and oxidative stress. In addition to activating Sirtuin1, it also It is possible to reduce oxidative stress and improve vascular function in aged mice through other means. For example, NMN can also affect the activity of Sirtuin3 in mitochondria, reduce oxidative stress, and enhance physiological function.

2. Repair DNA damage

In addition to affecting the activity of Sirtuins, NAD+ levels in the body are also important substrates for DNA repair enzymes PARPs (polyadenosine diphosphate-ribose polymerase).

In 2017, a research team led by Professor David Sinclair of Harvard Medical School discovered the mechanism of NAD+ repairing DNA damage. As NAD+ levels decline with age, the DNA repair enzyme PARP1 is increasingly bound by DBC1 (deleted breast cancer factor 1) to form a PARP1-DBC1 complex, which prevents PARP1 from repairing damaged DNA. Increasing NAD+ levels interferes with PARP1-DBC1 complex formation, thereby restoring the DNA repair activity of PARP1. Oral NMN was found to reduce DNA damage in aged mice exposed to radiation for a week. The research results were published in the journal Science.

3. Supports metabolism

In 2019, a study by Professor Nina Klimova of the University of Maryland School of Medicine and others found that intraperitoneal injection of NMN significantly increased the level of mitochondrial NAD+ in the hippocampus of experimental mice, and the level of energy molecule ATP in brain tissue increased, thereby improving the body's bioenergy metabolism. In addition, NMN can also increase the activity of antioxidant enzymes in mitochondria and reduce the production of reactive oxygen species.

4. Prevent bone density decline, improve vision, immune function

In 2016, a research team led by Professor Shinichiro Imai of the University of Washington School of Medicine conducted long-term experiments with oral administration of NMN to mice. Mice given NMN orally for 12 months compared with normal aging mice without NMN found that oral NMN was quickly converted into NAD+ in tissues and effectively eliminated various aging-related physiological declines: Prevention of aging-related weight gain , Improve metabolism, increase physical strength, improve insulin sensitivity and plasma fat indicators, improve vision, improve immune function, prevent bone density decline, etc. Moreover, NMN has no toxicity and side effects.

Tag: NMN , nicotinamide mononucleotide , NAD

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