The relationship between NMN and NAD+

NMN is the abbreviation of β-Nicotinamide Mononucleotide, which naturally exists in living cells and is the precursor of NAD+ (nicotinamide adenine dinucleotide).

As an essential coenzyme in the redox process, NAD+-dependent adenosine diphosphate ribosyltransferase, ring-sourced ADP-ribose polymerase, and type III histone deacetylase, the only substance that can be used, participates in cell material metabolism, energy Synthesis, cell DNA repair and other physiological activities.

NAD+ and circadian clock regulation：

Biological clock regulation is closely related to many diseases, including sleep disorders, diabetes, tumors, etc.; the occurrence and development of many diseases are triggered by circadian clock disorders.

There are many factors for the disorder of the biological clock, which may come from genetics or the environment. Keeping the normal work of the biological clock plays an extremely critical role in maintaining the health of the body and delaying aging.

Studies have found that NAD+ regulates the biological clock through SIRT1: the NAD+-dependent deacetylase SIRT1 establishes a bridge between circadian rhythm and metabolism by regulating the enzyme feedback loop of the NAD+ salvage pathway.

SIRT1 antagonizes the acetylation function of CLOCK by deacetylating BMAL1 and PER2, thereby inhibiting the transcription of clock genes mediated by CLOCK-BMAL1.

Therefore, NAD+ affects the deacetylation activity of SIRT1 through its own content level, which in turn affects the expression of a series of circadian clock-related proteins including NAMPT.

▲Interaction of NAD cycle and SIRT1

As the precursor of NAD+, NMN can significantly increase the NAD+ content in the body, thereby delaying, improving, and preventing various aging-related manifestations, as well as metabolic disorders and senile diseases caused by age.

Tag: β-nicotinamide mononucleotide, NMN

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