The role of NMN in delaying aging

Aging is a subject that humans have been studying. Because in addition to aging itself, aging can also cause many related diseases, including cardiovascular diseases, neurodegenerative diseases, metabolic syndrome, cancer, etc. The decrease in NAD+ levels caused by impaired NAD+ synthesis or increased NAD+ consumption is closely related to the occurrence of these diseases.

β-NMN increases NAD+ levels in animals and exerts its functions through NAD+.

Research shows that NAD+ levels gradually decrease with age and certain disease conditions, and NMN may exert anti-aging effects by increasing NAD+ levels.

Mills et al. conducted long-term experiments on mice that took NMN orally for 12 months. The results showed that compared with mice that took NMN orally for 12 months and normal aging mice that did not take NMN, they found that NMN entered the mice and was quickly converted into NAD+ in the tissues. NMN treatment can effectively alleviate age-related physiological decline and immune function decline in mice, promote physical activity, improve insulin sensitivity, improve insulin sensitivity and plasma fat indicators, improve vision, improve immune function, etc., and NMN does not have any Toxicity and side effects.

Sinclair et al. gave 22-month-old mice NMN for 6 days and found that the mice's muscle capacity, metabolism and endurance were improved. Mitochondrial dysfunction is a characteristic of individual aging and is closely related to stem cell aging.

Wang Huan's research shows that NMN improves the mitochondrial function of cells through the NAD+/Sirt3 pathway. Overexpression of Sirt3 can significantly reduce senescent cells in aging mesenchymal stem cells, and has the effect of inhibiting the aging of mesenchymal stem cells. Sirt3 is an NAD+-dependent deacetylase in mitochondria that can regulate intracellular ATP and mitochondrial electron transport. It can upregulate the activity of superoxide dismutase (SOD) through deacetylation modification, thereby clearing the activity in mitochondria. Oxygen, reducing oxidative stress damage within cells.

Studies have shown that up-regulating Sirt3 gene expression can restore the youthfulness of aging hematopoietic stem cells and effectively improve the function of aging cells.

Tag: NMN

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