Clinical Application Of Citicoline Sodium

Citicoline sodium is an activator of brain metabolism, which can promote brain cell respiration, improve brain function, promote recovery, and reduce cerebrovascular resistance. It can not only treat neurological diseases caused by craniocerebral injury and cerebrovascular accident, but also Adjuvant therapy for Kinson's syndrome and Alzheimer's disease has obvious clinical effects on acute stroke, nerve damage and disturbance of consciousness caused by surgery, and also improves amblyopia, strabismus, and glaucoma.

1. Brain disease

Citicoline Sodium is an intermediate product of phosphatidylcholine biosynthesis. After cerebral ischemia, Citicoline Sodium increases the stability of cell membranes, increases glutathione levels, inhibits phospholipid hydrolysis and arachidonic acid production, Thus limiting the generation of oxygen free radicals and lipid peroxides. At the same time, the drug can also increase cerebral blood flow, promote energy metabolism in the brain, improve cerebral circulation, and thus play a neuroprotective role.

Experiments have shown that the use of high-dose citicoline sodium at the beginning of craniotomy for severe craniocerebral injury can better prevent brain swelling and encephalocele to reduce secondary damage to brain tissue.

Citicoline sodium can also change the physiological function of meninges, improve cerebral vascular tension, increase cerebral blood flow and oxygen consumption, promote consciousness, and improve the symptoms of hemiplegia caused by stroke.

2. Nervous system diseases

Citicoline sodium and diacylglycerol are catalyzed by enzymes to generate phosphatidylcholine, which constitutes a bilayer lipid membrane. When the nerve cell membrane is damaged, exogenous citicoline continuously replenishes raw materials to synthesize phosphatidylcholine, which can repair nerve cell membrane, prevent peripheral nerve cell apoptosis, promote peripheral nerve regeneration, and then improve facial nerve pathological damage to treat facial nerve. inflammation.

Citicoline sodium contains neurotrophic substances that promote the recovery of nerve function, stimulates the growth of sympathetic nerve cells, promotes the repair of nerve cells, reduces cerebral vascular resistance, increases cerebral blood flow, and increases blood supply to lesions. It also shows a positive therapeutic effect in the treatment of sudden deafness, hyperemesis gravidarum, young amblyopia and other diseases.

3. Parkinson’s disease

Experiments have shown that citicoline sodium adjuvant therapy for Parkinson's patients can improve the therapeutic effect and effectively improve the neurocognitive function of patients. Citicoline sodium can be hydrolyzed to produce choline and cytidine, and choline is an important factor in the process of lecithin synthesis. Coenzyme, and lecithin is an important part of the cell membrane. When choline is acetylated into acetylcholine, the synthesis of the neurotransmitter acetylcholine in the cell will increase, and the integrity of the central nervous system function will be improved by exciting the cholinergic nerve. protection, thereby enhancing cerebral cortex function and reducing neural function and cognitive impairment.

In addition, citicoline sodium can increase the activity of mitochondrial ATPase and membrane NaK-ATPase, stabilize the nerve cell membrane and ensure the integrity of the synaptic structure of neurons, and reduce the apoptosis of nerve cells.

4. Glaucoma

Experimental studies have shown that citicoline sodium can enhance the transmission of retinal dopamine transmitters, and by affecting the level of retinal catecholamines, it can enhance the visual function of patients with glaucoma or amblyopia, prevent visual field deterioration, and improve the quality of life of patients.

Tag: Citicoline Sodium

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