NMN May Improve Diabetic Complications

Diabetes is divided into type 1 and type 2. Type 1 diabetes is derived from congenital inheritance and is an absolute lack of insulin. It occurs mostly in adolescence and requires lifelong insulin injections. What we usually call "eating diseases" refers to type 2 diabetes. It is caused by genetic and lifestyle factors and is closely related to insulin resistance, accounting for more than 90% of the total number of patients.

In people with type 2 diabetes, the insulin in the body is passively slowed down (reduced insulin sensitivity), and the ability to absorb blood sugar is reduced. As a result, the body obviously secretes more insulin, but does less work, which is called "insulin resistance".

Restoring insulin to work is especially important for people with type 2 diabetes.

A large number of studies have found that the decline of NAD+ levels is closely related to the development of various metabolic disorders including diabetes, and increasing NAD+ levels through NMN can help prevent and improve metabolic disorders.

As early as 2011, the team of Professor Shinichiro Imai of the University of Washington published research results: intraperitoneal injection of NMN can improve glucose tolerance and lipid distribution in type 2 diabetic mice by increasing NAD+ levels, enhance liver insulin sensitivity and restore oxidative stress , inflammatory response, and circadian rhythm-related gene expression.

In 2016, the team of Professor Shinichiro Imai published a study in the Sub-Journal of Cell, which further confirmed the control effect of NMN on hyperglycemia: experimental mice taking NMN for 12 months not only improved insulin sensitivity and lipid characteristics, but also inhibited the age Associated weight gain (obesity is closely related to insulin resistance).

With the deepening of the research, the scientists found that the NAD+ level in the adipose tissue of obese mice and aged mice decreased, which was related to severe insulin resistance in multiple organs. NMN can reverse insulin resistance, reduce free fatty acid concentration in plasma, repair mitochondrial function, improve glucose tolerance...

Research published by the University of Maryland in 2021 showed that NMN can prevent diabetic peripheral neuropathy and significantly reduce the increase in triglycerides and free fatty acids in diabetic rats.

Tag: NMN

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