NMN prevents lung cells from entering senescence

1. NMN protects aging lung cells from functional decline

The entry of lung cells into a senescent, non-proliferative state (senescence) causes disease, which researchers were able to prevent in mice using Nicotinamide Mononucleotide (NMN).

Supplementing aged mice with NMN protected lung cells from entering a stress- and age-induced state called senescence that promotes lung disease.

Second, NMN treatment can reduce lung structural damage after exposure to lung scarring agents.

Studies have shown that NMN can prevent and prevent the aging of lung cells that can lead to disease. When age takes full advantage of our lungs and induces lung disease, the lung cells responsible for oxygen exchange with the blood, called alveolar epithelial cells (AECs), lose function and decrease in number. How these cells decrease in function and number with aging is not fully understood, but scientists think it has something to do with them entering a non-proliferative state called senescence.

A study published in MedComm from the China National Geriatrics Clinical Research Center shows for the first time that the molecule NMN reduces cellular senescence and promotes lung health in aged mice. By giving mice 500 mg/kg/day of NMN in drinking water, they found that NMN reduced the levels of age-related proteins in the lungs of mice and attenuated chemically induced and age-related lung damage. "Dietary supplementation with NMN may be a new and effective way to prevent and reduce aging-related lung disease and stress-induced lung injury in the future," says Dr.

3. Lung NAD+ levels decrease during aging

NMN is a precursor to nicotinamide adenine dinucleotide (NAD+), a key molecule in metabolism and DNA health whose levels decrease with age in many cell types and organs, including the lung .

Age-related diseases such as cardiovascular diseases, neurodegenerative diseases, and metabolic disorders are all associated with age-related reductions in NAD+ levels, and studies have shown that NMN can alleviate various age-related diseases in mice.

4. NMN reduces the accumulation of age-related proteins

The same was true for the effect of NMN on the levels of p21, a protein that links the accumulation of DNA damage to the cessation of cell proliferation during aging. Decreased levels of p16 and p21 in the lung suggest that NMN can attenuate aging of lung tissue and protect it during aging.

Aging-related proteins were reduced in the lung tissue of mice supplemented with NMN. Young and aged mouse tissues stained for the senescence-associated proteins p16 and p21 are shown together with aged mice given NMN by drinking water (DW) or oral gavage (G), an accurate method of fluid consumption.

5. NMN prevents lung cells from entering senescence

To further investigate whether NMN directly prevents AEC senescence, the effect of NAD+ precursors on AEC induced senescence in two different ways. When grown in laboratory dishes, NMN treatment significantly reduced the number of lung cells that entered replicative senescence -- a state in which cells no longer proliferate after undergoing too many divisions. The lung cells were stressed by treating them with an antibiotic called bleomycin, which is known to induce lung cell senescence. NMN treatment was found to significantly reduce the number of senescent cells following bleomycin antibiotic stress, and these findings suggest that NMN protects against over-replication and stress-induced senescence.

6. NMN protects lung structure and function under stress

To test the effect of NMN on overall lung structure, the researchers treated mice with bleomycin, made them cough, and then inhaled the antibiotic, which causes the destruction of lung tissue. When these mice were treated with NMN, they found less destruction of lung tissue. The team also found that bleomycin-treated mice given NMNs had reduced numbers of inflammatory cells in their lungs and reduced total lung weight.

Since treatment of mice with bleomycin induces lung scarring, and accumulation of lung scar tissue promotes heavier lung weight, these results suggest that NMN treatment prevents aging-associated lung scarring.

7. NMN may provide protection against age-related lung disease

The data suggest that NMN can effectively alleviate [alveolar epithelial cell] replication and stress-induced senescence. Showing that boosting NAD+ levels with NMN prevents age-related aging of lung cells, the findings suggest that reduced NAD+ levels may play a role in aging.

In addition, NMN can ameliorate cellular senescence associated with decreased NAD+ levels. Dietary supplementation with NMN may be a new effective means to prevent and reduce age-related lung disease and stress-induced lung injury in the future.

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