Reduced glutathione is closely related to the immune regulation function of stem cells.

In addition to the damage protection of stem cells, reduced glutathione is also closely related to the immune regulation function of stem cells.

For example, ALLAMEH et al. found that when bone marrow mesenchymal stem cells differentiate into hepatocytes, the depletion of reduced glutathione can lead to the production of pro-inflammatory factors such as interleukin-6, interleukin-8, and tumor necrosis factor α, and promote cellular inflammation. On the contrary, the increased synthesis of reduced glutathione induces the production of anti-inflammatory factors such as interleukin-10, which inhibits the inflammatory response.

Intracellular glutathione levels are also involved in the restoration of inflammatory markers and signals, which can improve the imbalanced state of cytokines during stem cell differentiation.

Human placental mesenchymal stem cells can reduce the production of reactive oxygen species by increasing the levels of reduced glutathione and glutathione-S-transferase, further reducing the expression of T cell surface protein PD-1, and successfully inhibiting PD- The generation of 1+T lymphocytes, thereby reducing the inflammatory response in mice with graft-versus-host disease, can promote the production of intracellular antioxidant molecule glutathione by increasing N-acetyl-L-cysteine in acute inflammatory state. generation, enhance the anti-oxidative stress defense ability of BMSCs, enhance anti-inflammatory activity and promote the process of bone regeneration after BMSCs transplantation.

It is commonly used in the treatment of severe acute pancreatitis and other inflammations. One is to prevent cell damage and release inflammatory factors to indirectly play an anti-inflammatory effect, and the other is to inhibit the inflammatory response by directly affecting the expression of inflammatory substances.

Tag: glutathione

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