Related Research in The Field Of NMN

In recent months, more functions of NMN have been unearthed by scientists:

1. NMN treatment of polycystic ovary syndrome, fasting insulin level completely returned to normal state.

Polycystic ovary syndrome (PCOS) is a common endocrine disease in women, characterized by hyperandrogenism, ovulatory disorders, and polycystic ovarian changes, especially in women of puberty and reproductive age, with an incidence of 5% to 10%. Polycystic ovary syndrome often causes metabolic disorders, including insulin resistance, obesity, and hepatic steatosis.

The treatment of polycystic ovary syndrome is quite difficult, and there are few treatment methods, usually choosing to suppress androgen that is too high. Recent studies have found that NAD+ levels in patients with polycystic ovary syndrome will be significantly reduced. Scientists speculate that NMN or Can treat polycystic ovary syndrome.

A recent study published in Molecular Metabolism by The University of New South Wales confirmed previous speculation, finding that NMN fully restores metabolic dysregulation caused by PCOS. They gave female mice with polycystic ovary syndrome NMN for 8 weeks and found that the fasting insulin levels of the treated mice were almost close to those of normal mice, and hyperinsulinemia, obesity and liver lipid deposition were significantly improved. , while NAD+ levels in the muscles were also restored.

2. NMN improves inflammatory bowel disease and promotes the growth of probiotics.

Inflammatory bowel disease is a chronic nonspecific intestinal inflammatory disease of unknown etiology, mainly including ulcerative colitis and Crohn's disease. Among them, Crohn's disease is incurable due to repeated symptoms, and some people call it "immortal cancer". Today, NMN seems to offer hope.

Scientists from Jiangsu University published their research results in Current Research in Food Science. They found that after NMN treatment, the intestinal morphology and barrier function of mice were improved, the colon length was slightly restored, and the expression of pro-inflammatory factors was also reduced. . In addition, the intestinal flora imbalance was also repaired, and the abundance of beneficial bacteria such as Lactobacillus, Akkermansia and Firmicutes was significantly increased. NMN improves inflammatory bowel disease from three aspects: intestinal inflammation, intestinal barrier and intestinal flora.

3. Diabetes can easily make men infertile, and oral NMN promotes spermatogenesis.

Diabetes is known to cause all kinds of complications, and what you may not think of is that it can even affect the reproductive system. For men, diabetes can cause problems such as decreased libido, erectile dysfunction, infertility, and abnormal sperm.

Recently, the University of South China published the research results of its team in Acta Biochimica et Biophysica Sinica. They found that oral administration of NMN for 8 weeks can significantly increase the testicular weight and sperm count of diabetic mice, and significantly reduce the abnormal sperm count and sperm deformity rate. . The researchers believe that this is because NMN protects male reproductive function by reducing spermatogenic cell apoptosis by regulating glycolysis, an energy metabolism process in Sertoli cells.

NMN exerts its protective effect by regulating glycolysis in Sertoli cells of the testis of diabetic mice and reducing apoptosis of spermatogenic cells.

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