Study On The Biological Efficacy Of Β-Nicotinamide Mononucleotide

Nicotinamide Mononucleotide is an intermediate in the salvage synthesis pathway of nicotinamide adenine dinucleotide in mammals. Recent studies have found that artificial supplementation of NMN can repair brain damage,β-Nicotinamide Mononucleotide improve pancreatic islet function, protect the heart from ischemia-reperfusion injury, repair brain mitochondrial respiratory defects,β-Nicotinamide Mononucleotide and be effective for elderly degenerative diseases, retinal degenerative diseases, type 2 diabetes,β-Nicotinamide Mononucleotide cerebral hemorrhage, etc. Both have a certain therapeutic effect.

NMN (nicotinamide mononucleotide) is the product of nicotinamide phosphoribosyl transferase reaction and is one of the key precursors of NAD+. In mammals,β-Nicotinamide Mononucleotide NMN is produced by nicotinamide under the catalysis of Nampt, β-Nicotinamide Mononucleotideand then NMN is produced under the catalysis of nicotinamide mononucleotide adenosyltransferase to produce NAD+. Extracellular NMN needs to be dephosphorylated and converted into nicotinamide riboside to enter the liver cell. After entering the cell, NR is phosphorylated under the action of nicotinamide riboside kinase 1 to produce NMN,β-Nicotinamide Mononucleotide and then NMN and ATP combine to produce NAD+. NMN is converted into NAD+ in the human body to exert its physiological functions, such as activating the NAD+ substrate-dependent enzyme Sirt1 (histone deacetylase, also known as sirtuin), regulating cell survival and death,β-Nicotinamide Mononucleotide and maintaining redox state.

Recent studies have found that by regulating the level of NMN in the organism,β-Nicotinamide Mononucleotide it has a better therapeutic and repairing effect on cardiovascular and cerebrovascular diseases,β-Nicotinamide Mononucleotide neurodegenerative diseases and aging degenerative diseases; in addition,β-Nicotinamide Mononucleotide NMN can also play a role in participating in and regulating the body’s endocrine. To protect and repair pancreatic islet function, increase insulin secretion,β-Nicotinamide Mononucleotide prevent and treat metabolic diseases such as diabetes and obesity.

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