The Research Team Found That The Combination Of Intestinal Lactobacillus And NMN Can Prevent Skin Sunburn

UV radiation is generally classified according to wavelength as long-wave, medium-wave and short-wave. Among them, long waves can destroy the elastic fibers and collagen fibers in the skin, making the skin black and thick; medium waves can cause skin "sunburn". Moreover, under the same intensity of irradiation, the damage of medium-wave ultraviolet rays to the skin is 800-1000 times that of long-wave ultraviolet rays. Therefore, preventing the damage of medium-wave ultraviolet rays to the skin is the key to preventing ultraviolet burns.

Recently, a research team from Chongqing Second Normal University published a study in the journal "Front Pharmacol" showing that the combination of NMN and intestinal bacteria "Lactobacillus fermentum" can significantly reduce the damage of ultraviolet rays to the skin of mice. damage. The researchers said that the combination of "NMN" and Lactobacillus fermentum may be an effective way to protect the skin from UV burns.

There are many factors that cause skin aging. In addition to genetic factors, the external environment and ultraviolet rays will cause cell oxidation to generate free radicals, thereby accelerating skin aging. Therefore, the ability of active substances to clear free radicals is also an important indicator to measure the antioxidant capacity. In order to test the antioxidant capacity of NMN and Lactobacillus fermentum, the researchers added NMN, Lactobacillus fermentum, vitamin C and a mixture of NMN and Lactobacillus fermentum to the test tubes containing free radicals.

It was found that the combined use of NMN and Lactobacillus fermentum increased the free radical scavenging ability by about 30% compared with the supplementation of NMN alone, and increased the free radical scavenging ability by 15% compared with the supplementation of Lactobacillus fermentum alone. In addition, as a powerful and common free radical scavenger, vitamin C was also included in this study by the researchers as a control. The results showed that the combined use of NMN and Lactobacillus fermentum significantly improved the free radical scavenging capacity, and its antioxidant capacity was also stronger.

Comparison of in vitro antioxidant capacity of each experimental group (L refers to Lactobacillus fermentum)
Note: OH, ABTS and DPPH are usually used to test the free radical scavenging ability of a substance

In order to further explore the repairing effect of Lactobacillus fermentum combined with NMN on damaged skin. The researchers randomly divided 60 mice into 6 groups, namely normal group, vitamin C group, NMN group, Lactobacillus fermentum group, NMN+Lactobacillus fermentum group and control group. Subsequently, except for the mice in the normal group, the thickness of the dermis of the mice in the other groups was significantly reduced, the number of collagen fibers was reduced, the arrangement of the subcutaneous tissue was disordered; and the number of inflammatory cells increased by 4 times. This suggests that the UV photos caused damage to the skin structure and triggered skin inflammation.

The results showed that the epidermis of the mice in the normal group was thin, the dermis was thicker, and the collagen fibers had a complete morphology, orderly arrangement and even distribution. In the control group, the thickness of the dermis was significantly thinner, the number of collagen fibers was reduced, and the arrangement of subcutaneous tissue was disordered; the number of inflammatory cells increased by 4 times. This suggests that UV exposure damages the skin structure and triggers skin inflammation.

At the same time, the researchers also found that compared with the control mice, the vitamin C, NMN group, Lactobacillus fermentum group, and NMN+Lactobacillus fermentum group had increased collagen fibers and decreased inflammatory cells. Among them, the effect of the mice in the NMN+Lactobacillus fermentum group was the most significant, and the number of inflammatory cells was reduced by 50%. This shows that the combined use of NMN and Lactobacillus fermentum can significantly reduce the damage of ultraviolet rays to the skin and have a stronger protective effect on the skin.

Comparison of skin conditions under different experimental combinations

In summary, this study confirms that NMN and intestinal flora "Lactobacillus fermentum" used alone can scavenge free radicals in mice and enhance the antioxidant capacity of the skin. However, the effect of the combination of the two is more significant, which can significantly reduce the damage of ultraviolet rays to the skin. The researchers believe: "This provides a new means of protection for people to resist ultraviolet radiation and delay skin aging."

Tag: NMN

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