β-Nicotinamide mononucleotide plays an important role in the production of human cellular energy and participates in the synthesis of intracellular NAD (nicotinamide adenine dinucleotide, an important coenzyme for cellular energy conversion). Nicotinamide (nicotinamide) is a derivative of vitamin B3, also known as niacin. NAD+ is a molecule with multiple functions in the body, primarily by promoting cell signaling enzymes called sirtuins. These enzymes are required for normal function, and SIRT1 (of which there are seven sirtuins) is particularly unique. Studies have shown that it is very active after calorie restriction, which in itself brings a variety of benefits, including signs of increased lifespan. Sure enough, further testing showed that elevated levels of SIRT1 protected against metabolic decline and disease.
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