Citicoline in traumatic brain injury: Accelerated recovery of consciousness and improved cognitive impairment

Traumatic brain injury (TBI) is one of the most devastating types of injury, leading to diverse neurological and cognitive deficits and even death in the most severe cases. The management of TBI focuses on reducing the severity of sequelae and improving recovery from these sequelae, and neuroprotection is one of the optimal options for TBI treatment.

Citicoline has been used in the treatment of cerebral ischemia-related diseases such as TBI. Citicoline can restore the integrity of the blood-brain barrier, reduce the duration of coma caused by different mechanisms, increase the incorporation and metabolism of glucose, and reduce the lactate level in the brain during ischemia.

Citicoline exerts multiple neuroprotective effects:

●Protect and repair neuron membrane.

●Normalization of phospholipid content in membranes.

● Normalization of neuronal membrane function.

●Normalization of ion exchange across neuronal membranes.

● Restoration of the activity of certain enzymes (CTP: cytidine phosphoryltransferase, ...).

● Improve neurotransmission (acetylcholine, dopamine, etc.).

●Improve brain metabolism.

●Restores membrane-bound ATPase activity.

●Inhibit the activity of phospholipase, avoid releasing free radicals and second messengers.

●Enhance antioxidant and anti-inflammatory mechanisms.

● Accelerate the reabsorption of cerebral edema.

●Reduce the volume of cerebral ischemic lesions.

●Inhibits apoptosis.

●Activate cellular repair mechanisms and neuroplasticity.

Clinical data show that: citicoline accelerates the recovery of consciousness and improves the sequelae of craniocerebral injury.

●Citicoline can accelerate the recovery of nervous system clinical symptoms and state of consciousness.

●Citicoline reduces the incidence of mortality and adverse outcomes, with high safety.

●Citicoline can effectively treat TBI-related cognitive impairment and improve the quality of life.

●Citicoline is effective in the treatment of mild TBI-related post-concussion syndrome, significantly improving memory and clinical symptoms.

In conclusion, citicoline is safe, effective and well tolerated for moderate to severe traumatic brain injury.

*Disclaimer: The content of this article is only for information and cannot replace the doctor's treatment diagnosis and advice. Always consult your healthcare provider for a diagnosis, accurate medical information, and clearance before taking any supplement.

Reference: Secades JJ. Role of Citicoline in the Management of Traumatic Brain Injury. Pharmaceuticals (Basel). 2021 Apr 26;14(5):410.

Tag: Citicoline

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