nicotinamide mononucleotide (NMN) on each Effects of age-related health and disease groups

Recently, the team of Daniel H Craighead and Kaitlin A Freeberg of the University of Colorado in the United States published a review in the Journal of Gerontology published by Oxford University Press, analyzing the effect of NAD+ supplementation pathway - Nicotinamide Mononucleotide (NMN) on each Effects of age-related health and disease groups, especially on older adults.

No.1 general healthy population

In nine trials of 4- to 12-week duration, subjects received NMN at a dose up to 1200 mg/day, with no adverse effects reported and well tolerated.

Among them, taking 250mg of NMN per day, after 12 weeks, the NAD+ level in the whole blood of the subjects can be increased by up to 6 times; the concentration of nicotinamide in the serum can be increased by about 60%. In the experiment of taking 300 mg per day for 8 weeks, a 4-fold increase in the abundance of nicotinamide in the blood of participants was observed, accompanied by a decrease in hemoglobin A1c (blood sugar concentration index) and an increase in high-density lipoprotein cholesterol.

In terms of exercise, taking 250mg of NMN per day for 12 weeks can significantly increase the walking speed and grip strength of 65-year-old participants; taking more than 600mg per day, the six-minute walk test results of 40-65-year-old people are about 30% stronger than before the experiment. 1.5 times.

No.2 Obese and sick people

The article reviewed three trials for obese people, and the results showed that short-term intake of NMN at a dose of 2000 mg/day can increase the concentration of NAD+ in whole blood by about 200%. After discontinuation of treatment, relevant NAD+ metabolites decreased to baseline levels.

In addition, the team of Hiromi Rakugi and Hiroshi Akasaka of the Osaka University School of Medicine in Japan found in a study of NMN in the treatment of elderly men with diabetes and impaired physical function that participants with an average age of 81 continued to take NMN for 24 weeks, which was safe and effective.

*Disclaimer: The content of this article is only for information and cannot replace the doctor's treatment diagnosis and advice. Always consult your healthcare provider for a diagnosis, accurate medical information, and clearance before taking any supplement.

Reference: Freeberg, K., Udovich, C., Martens, C., Seals, D., & Craighead, D. (2023). Dietary supplementation with NAD +-boosting compounds in humans: Current knowledge and future directions. The Journals Of Gerontology: Series A. doi: 10.1093/gerona/glad106

Tag: nicotinamide mononucleotide , NMN

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