Development and use of NMN nutritional supplement

As a supplement that can boost NAD+ (nicotinamide adenine dinucleotide) levels, NMN has received much attention in the field of anti-aging and health.

At present, many research institutions and enterprises around the world are promoting the scientific research and commercial application of NMN.

Here is the latest progress of NMN in research and development, market application and usage.

1. NMN research and development progress

(1) Animal experimental research

Studies on NMN started from animal experiments, and several studies have shown that NMN may have anti-aging, enhance metabolism and improve health.

• 2013: Experiments by Professor David Sinclair of Harvard University found that NMN supplementation in mice reversed mitochondrial function decline, allowing 22-month-old mice (equivalent to a 60-year-old human) to revert to a 6-month-old (20-year-old human) state within a week.

• 2016: Experiments at Keio University in Japan showed that NMN can improve insulin sensitivity and energy metabolism in elderly mice, helping to prevent diabetes and obesity.

• 2019: Research from the University of Washington found that NMN improved vascular health and increased endurance in older mice.

(2) Human clinical trials

• 2019: Keio University conducted the first human safety trial of NMN and found that a single oral dose of 100-500mg of NMN did not cause serious side effects, demonstrating its safety.

• 2021: Research from the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, shows that continuous administration of NMN can significantly increase NAD+ levels, but the specific impact on life extension still needs more research.

• 2022-2023: Multiple clinical trials are underway in the United States, Japan, and Europe to study the specific efficacy of NMN in anti-aging, cardiovascular health, diabetes, exercise capacity, and more.

Although the animal results are encouraging, human clinical studies are still in the early stages, and long-term effects and safety need to be further validated.

2. Market application and usage of NMN

(1) Global NMN nutritional supplement market

The NMN supplement market has grown rapidly since 2018 and the global market size is expected to exceed $1 billion by 2025.

Currently, major markets include:

• • USA: Led by Elysium, Tru Niagen, DoNotAge and others.

• • Japan: Shinkowa, Orihiro and other brands sell well, and some products add antioxidant ingredients such as Q10 and resveratrol.

• • China: GeneHarbor /GSHWORLD is the main brand, with several local brands entering the market.

• • Europe: Brands such as DoNotAge and Renue by Science are popular.

(2) Main consumer groups

NMN is mainly popular with the following groups:

• ✅ Middle-aged and elderly people (over 50 years old) : hope to delay aging, improve energy, enhance memory.

• ✅ High-intensity workers (executives, researchers, etc.) : want to improve fatigue and focus.

• ✅ Athletes or bodybuilders looking to improve endurance and muscle repair.

• ✅ People at high risk for diabetes and cardiovascular disease: want to improve metabolic health (subject to doctor's guidance).

(3) Common NMN administration methods

• • Oral capsules (most common, easy to absorb)

• • Tablet or powder (can be taken with water or drink)

• • Sublingual lozenges (faster absorption)

(4) The combination of NMN and other anti-aging ingredients

Many NMN supplements are paired with other anti-aging ingredients, such as:

• • Resveratrol: enhances antioxidant effect and improves NMN activity.

• • Coenzyme Q10 (CoQ10) : Improves mitochondrial function and enhances energy metabolism.

• • PQQ (pyrrorole quinoline quinone) : promotes the formation of new mitochondria and enhances fatigue resistance.

3. Disputes and future development of NMN use

(1) Does NMN really extend life span?

• The current study is mainly based on animal experiments, and while NMN has shown anti-aging and health-improving effects in mice, long-term life-extending effects in humans have not been demonstrated.

Many scientists believe that NMN may mainly improve health and quality of life, not necessarily significantly extend life span.

(2) Controversy over NMN regulation by FDA

In 2022, the US FDA temporarily rejected NMN as a dietary supplement due to its use in drug research (filed by Metro International Biotech), resulting in a conflict of regulations.

Currently, NMN can still be sold in the US market, but regulatory policies may change in the future.

(3) Future development trend

• • More clinical trials: More human trial data will be available over the next 3-5 years to validate the long-term safety and efficacy of NMN.

• • Compound formulation development: NMN may be combined with other anti-aging ingredients (e.g. Resveratrol, PQQ, Q10) to improve the overall effect.

• • Precision nutrition: Genetic testing +NMN program may be introduced in the future to customize NMN supplements according to individual genetic conditions.

Sum up

• ✅ NMN has shown anti-aging and metabolic potential in animal studies, but its long-term effects in humans need further study.

• ✅ At present, NMN is mainly used as a nutritional supplement, which is welcomed by middle-aged and elderly people, enterprise executives, athletes and other groups.

• ✅ The global NMN market is growing rapidly, but it is facing certain regulatory disputes in the United States, and its future development remains to be observed.

• ✅ The safety and effects of long-term use of NMN need more human trials to support, and blind high dose is not recommended.

Tag: NMN , nmn supplement

Supplier Introduction: China glutathione supplier and NMN manufacturer GSHworld, the company mainly develops biotechnology and industrialization. As a global pioneer in enzymatic catalytic ATP regeneration technology, our company advocates green production and is committed to providing customers with better and more environmentally friendly products and services. Glutathione Manufacturer,NMN Factory,Citicoline Sodium supplier,China NMN manufacturers