Eat NMN before drinking can cure wine to protect liver?

Many friends around us who blush when they drink alcohol are the manifestation of insufficient acetaldehyde metabolism. They are more likely to develop DNA damage under the influence of acetaldehyde, a metabolite of alcohol, and are more likely to cause related diseases.

NMN has certain effects of antialcoholism and liver protection

mainly reflected in the following aspects:

1. Accelerate alcohol catabolism

There are three main steps in alcohol catabolism: first alcohol (ethanol) is converted to acetaldehyde under the action of ethanol dehydrogenase (ADH) and NAD+, then acetaldehyde is converted to acetic acid under the action of aldehyde dehydrogenase 2 (ALDH2) and NAD+, and finally acetic acid enters the tricarboxylic acid cycle and is converted to carbon dioxide and water.

In this process, NAD+ plays a key coenzyme role.

NMN is a direct precursor of NAD+, and supplementation of NMN can rapidly increase the content of NAD+ in the liver, thus accelerating the catabolism of alcohol in the liver, and playing a rapid role in antialcoholism.

2. Protect your liver from alcohol damage

Preventing elevated markers of liver damage:

Plasma ALT (alanine aminotransferase) and AST (aspartate aminotransferase) are biomarkers of liver injury.

It was found that NMN supplementation could prevent ethanol-induced elevation of ALT and AST and reduce the damage of alcohol to liver cells.

Regulating gene expression:

Ethanol can significantly change the expression of some genes in the liver, and NMN treatment can reduce the effect of ethanol on some genes.

For example, NMN prevents ethanol-induced overexpression of ATF3, a stress response transcription factor whose overexpression has harmful effects on the liver.

At the same time, NMN can restore erk1/2 signal transduction, extracellular signal regulation kinase 1/2 (erk1/2) plays a role in metabolism, cell cycle and cell survival, and NMN can prevent ethanol from inhibiting the phosphorylation of erk1/2.

Reduces oxidative stress and steatosis in the liver:

Long-term alcohol consumption can lead to increased oxidative stress and steatosis in the liver, and NMN can increase the level of NAD+ in the liver, enhance the antioxidant capacity of the liver, reduce the damage of liver cells caused by oxidative stress, and help restore the content of TCA circulating metabolites, improve the metabolic function of the liver, and reduce steatosis.

Prevent liver fibrosis:

Alcoholic liver disease, if not prevented and treated, can easily evolve into serious diseases such as cirrhosis and liver cancer.

Studies have shown that NMN can prevent the uncontrolled accumulation of scar tissue called fibrosis in the liver, playing a role in preventing liver fibrosis.

Tag: NMN

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