NMN maintains balance of immune system - Knowledge

NMN maintains balance of immune system

Mar 12, 2025 / Author: China Glutathione suppliers & NMN manufacturers

NMN maintains the balance and stability of the immune system by enhancing the level of NAD+, activating immune cells, regulating signaling pathways in immune cells, and participating in DNA repair.

NMN maintains balance of immune system

Boosts NAD+ levels to provide energy for immune cells

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme of many enzymes in the cell and is involved in a variety of important biochemical reactions, including energy metabolism, gene expression regulation and DNA repair.

As a precursor of NAD+, NMN supplementation can significantly increase the intracellular NAD+ content.

This provides a basic guarantee for the normal function and activity of immune cells, because the activation and function of immune cells need to consume a lot of energy and nutrients, and their metabolic state has an important impact on the intensity and duration of immune response.

Activate immune cells and enhance immune function

Activate macrophages

Macrophages are an important line of defense for the immune system, able to engulf and eliminate invading microbes while releasing cytokines to regulate other immune responses.

By supplementing with NMN, it is possible to increase the activity of macrophages, making them more effective at removing pathogens, thus boosting immunity.

Promote T cell proliferation and differentiation

T cells are one of the key cell types in the immune system and play a central role in cellular immunity.

By increasing the level of NAD+ and activating SIRT1 protein (a NAD+ dependent deacetylase), NMN can promote the proliferation and differentiation of T cells, increase the number of effector T cells and memory T cells, and thus enhance the body's specific immune response to pathogens.

Enhance the activity of natural killer cells

Natural killer cells (NK cells) can directly recognize and kill tumor cells, virus infected cells and other abnormal cells, and play an important role in the body's immune surveillance.

NMN can improve the activity and lethality of NK cells, enhance their ability to recognize and clear tumor cells and virus-infected cells, and help maintain the immune homeostasis of the body.

Regulates signaling pathways within immune cells

NMN can maintain immune balance by regulating signaling pathways within immune cells.

For example, NMN regulates inflammatory signaling pathways in immune cells by activating SIRT1.

In inflammatory response, SIRT1 can inhibit the overexpression of pro-inflammatory factors, avoid the uncontrolled inflammatory response, and promote the production of anti-inflammatory factors to maintain immune balance.

This regulatory mechanism helps to reduce the occurrence of chronic inflammation and protect the body from inflammatory damage.

Participate in DNA repair and maintain stability of immune cell genomes

When immune cells respond to pathogens and environmental stimuli, their DNA is vulnerable to damage.

If the DNA damage cannot be repaired in time, it may lead to abnormal function of immune cells or even cell death, thus affecting the function of the immune system.

By increasing the level of NAD+, NMN can provide sufficient substrates for enzymes and signaling pathways related to DNA repair, thereby enhancing DNA repair ability.

This helps to maintain the stability of the immune cell genome, ensure the normal function and proliferation of immune cells, so that the immune system can continue to effectively play a defense role.

Tag: NMN

Supplier Introduction: China glutathione supplier and NMN manufacturer GSHworld, the company mainly develops biotechnology and industrialization. As a global pioneer in enzymatic catalytic ATP regeneration technology, our company advocates green production and is committed to providing customers with better and more environmentally friendly products and services. Glutathione Manufacturer,NMN Factory,Citicoline Sodium supplier,China NMN manufacturers

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