NMN opens new front in allergy

With pollen flying and pet hair flying, the arrival of allergy season makes millions of people with allergies miserable. Nasal congestion, runny nose, itchy skin, and even difficulty breathing, allergic reactions seriously affect the quality of life of people with allergies.

Anaphylaxis, specifically, is a biological reaction caused by antigens and antibodies, and is essentially an immune response. Allergy symptoms occur when the body's immune system overreacts to a harmless substance.

Scientific research has found that NMN is about to change this situation!

NAD+ has a regulatory effect on allergies

NMN - NAD+ enhancer, a novel strategy that could change the allergy landscape.

The study found that Sirt6 (Silencing message regulator 6) does play an important role in regulating mast cell activation in response to allergen exposure. This finding provides important clues for understanding the molecular mechanisms of allergic reactions and developing new anti-allergy therapies.

On the one hand, allergic reactions can reduce the level of NAD+ in mast cells, which affects the regulatory function of Sirt6.

On the other hand, it was found as early as 1974 that niacinamide, a precursor of NAD+, inhibits histamine release by mast cells, suggesting that NAD+ may inhibit allergic reactions.

NMN can effectively increase NAD+ levels, and this recent study also confirms their effect.

NMN effectively inhibits anaphylaxis in animal experiments

The researchers sensitized mouse bone marroe-derived mast cells (BMMCs) and found a significant decrease in the level of NAD+ within the cells. Injection of NMN significantly reduced IGE-mediated anaphylaxis, and NMN and NR significantly inhibited other stimulators that contribute to allergic inflammation, such as pro-inflammatory cytokines (TNF-α and IL-6) and arachidonic acid metabolites (PGD2 and LTC4).

Studies have shown that the regulatory mechanism of allergy is closely related to Sirt6, and these beneficial effects are attenuated in mast-cell-specific Sirt6 gene knockout mice. Treatment with NAD+ precursor NMN significantly inhibits IGE-mediated mast cell degranulation and allergic reactions, and increasing NAD+ levels helps to improve allergic inflammation.

Such NMN naturally has been sought after by a large number of consumers, according to the "2022-2023 Global and China anti-aging industry Development and consumer demand Research Report" released by imedia Consulting, the surveyed consumers spend more on NMN supplements than anti-aging skin care products.

NMN, as the star of anti-aging and immune-enhancing supplements, is favored both in the scientific research field and in the consumer market. Every year, a large number of NMN anti-aging studies are published in internationally renowned journals, showing a multi-faceted improvement effect.

With such appeal of NMN, if you are also interested, here are some notes to share with you!

Some NMN products on the market claim to be as pure as 99.9%, is it true?

Purity is one of the important indexes to evaluate the quality of NMN products. High purity NMN products can theoretically provide better results. However, it should be noted that in the production of NMN raw materials, other substances with similar molecular formulas will be produced at the same time, such as NR (nicotinamide ribose), NA (niacin), NAM (nicotinamide) and so on.

These substances may be mistaken for NMN in the ordinary profile test, resulting in high purity test results. Therefore, the pure purity of NMN does not mean that the product must be high quality, but also need to consider many other factors, such as the content of β-NMN, product stability and safety.

There are some shoddy phenomena in the market, so when choosing NMN products, in addition to paying attention to the purity index, it is also necessary to view the production process of the product, certification marks, word-of-mouth evaluation and other information.

It is recommended that consumers choose regular channels and well-known brands when purchasing NMN products to ensure the quality and safety of products.

How long does NMN work? Is it better to eat more?

The effect of taking NMN varies from person to person, but in general, you can see obvious effects after taking it for about a week, such as increased metabolic efficiency and improved mental state.

More is not always better. The current study suggests that 600mg of NMN per day may be a more effective dose choice. Excessive intake may increase the burden on the body and even cause unnecessary risks.

When taking NMN, the appropriate dosage should be determined according to the individual's physique, health condition and doctor's advice, and follow the product instructions.

Tag: NMN

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