Oct 12, 2024 / Author: China Glutathione suppliers & NMN manufacturers
With the increasing pressure of social survival and the increasing number of elderly people around the world, the demand for health care and anti-aging health care products is also increasing. People hope to regulate their health through supplements and reduce the occurrence of age-related diseases. Among the many supplements, Nicotinamide Mononucleotide (NMN) has been receiving attention from consumers and the scientific community.
NMN itself is found in food, and it can also be used as a supplement. There are two active forms of NMN, α and β-NMN.
As a precursor of nicotinamide adenine dinucleotide (NAD+), NMN can be produced by rescuing the synthetic pathway after absorption by human body.
Intracellular NAD+ levels decline with age, and reduced cellular NAD+ levels have been shown to cause a variety of health-related problems. Scientists say restoring NAD+ levels could delay or even reverse these problems.
NMN has been shown to have great therapeutic potential in the treatment of blood sugar, heart health, cognitive function, and many other health problems, with exciting research results.
A recent study in May 2022 evaluated the efficacy and safety of NMN in middle-aged and older adults. In this randomized, double-blind, placebo-controlled study, participants were measured for 30 and 60 days after taking NMN.
The results showed that the level of NAD+ in the cells of the subjects was significantly increased, and the increase of NAD+ was associated with the increase of cell energy level.
Elevated blood sugar can cause problems with the heart, arteries, weight control and the brain, while supplementing NMN into cells increases energy levels and has a positive effect on blood sugar levels, resulting in an anti-aging effect.
A 2020 CalerieHealth-funded animal study conducted at the University of Memphis in the United States found that NAD+ levels in the brain tissue of mice treated with NMN significantly increased by about 40% compared to control mice not treated with NMN, indicating that NMN can rapidly increase brain NAD+ levels across the blood-brain barrier.
During the aging process, many people will experience problems with sleep, mental and energy loss.
How can we improve our sleep, energy levels, quality of life and longevity?
Japanese scientists showed in a 12-week double-blind clinical study that NMN was able to improve sleep quality and lower leg function.
In this study, NMN also helped reduce sleepiness and boost energy, which in turn improved cognitive function and physical functioning.
The human body usually feels tired more frequently in the afternoon, because it has already passed the day's work and activities, and severe fatigue may have an adverse effect on the quality of sleep.
In this study, the correlation between NMN and time was found by studying the effects of taking NMN in the morning and afternoon.
While NMN can be taken at any time during the day, studies have shown that taking it in the afternoon or evening can improve calf function and feelings of fatigue.
Telomeres are located at the ends of human genetic material, the chromosomes, and their shortening has been linked to aging and health problems.
Scientific studies have found that NMN has a positive effect on the gut microbiota, and this remodeling of the microbiota significantly reduces aging by improving immunity and cofactor/vitamin metabolism.
Most notably, in subjects taking NMN, the telomere length of the cells was significantly extended. This suggests that oral NMN supplementation during pre-aging may be an effective strategy for delaying aging.
We can find that a large number of scientific studies focus on the effects of NMN on health and aging, with several research papers published in recent years.
CalerieHealth's animal studies have also shown that NMN significantly increases brain NAD+ levels, more than 40 percent higher than controls.
New research shows that NMN improves sleep, helps improve cognitive function and physical performance, increases NAD+ levels, doubles telomere length, and improves microbiota.
An experiment published in the journal Nature found that when old and non-senescent cells were labeled with special lipophilic dyes and transplanted into pre-injury muscle, only senescent cells delayed the regeneration of the young host's muscle.
Conversely, reducing senescent cells in animals increases the size of regenerated muscle fibers and reduces inflammation and matrix deposition.
Even in young muscle, senescent cells can be harmful.
To investigate the effects of aging on muscle cells alone, the study looked at basal cells in young and old mice.
In older mice, stromal/remodeling components, immune-inflammatory responses, DNA damage and cell cycle stoppage of lipid metabolism, stromal remodeling and insulin signaling genes are up-regulated, while genes associated with mitochondria are down-regulated.
The basal cells in the older mice also had more DNA damage than in the younger mice, which happened to coincide with higher levels of reactive oxygen species in the older mice. Factors affecting the cell cycle and inflammatory response were also more common in older mice than in younger ones.
Thus, injury and aging can lead to the accumulation of stressors and activation of inflammatory/fibrotic pathways, putting old cells into a senescent state, leading to a more severe state of senescence after injury.
Long-term oral supplementation of NMN partially improved muscle strength and performance in healthy older men, although NMN did not affect skeletal muscle mass (where muscle strength was assessed by gait speed, counting from a 30-second chair standing test, and grip strength).
Because damage and aging can lead to an increase in senescent cells and an increase in inflammatory response factors, if we can eliminate senescent cells or pro-inflammatory molecules secreted by senescent cells, it is possible to achieve anti-aging or delay aging.
A 2021 study found that NMN can inhibit LPS-induced macrophage activation by restoring the level of NAD+, thereby inhibiting a portion of macrophage inflammation, and the content of NAD+ also increases with the concentration of NMN.
Low cellular NAD+ levels in senescent cells have been shown to be associated with the development of a variety of age-related diseases.
For example, the aging of retinal pigment epithelial cells (RPE) is associated with oxidative stress and NAD+ depletion.
Significant DNA damage and mitochondrial dysfunction were also detected in aged retinal pigment epithelial cells.
NMN supplementation can strongly improve the aging of retinal pigment epithelial cells by alleviating DNA damage and maintaining mitochondrial function.
NMN has the potential to ameliorate RPE senescence and age-related pre-macular degeneration by restoring NAD+ levels in cells and tissues.
NMN can also improve the senescence of alveolar epithelial cells.
Alveolar epithelial cells (ACE) gradually age with age, which is one of the main causes of the decline in our respiratory system's defense and respiratory function.
NMN was found to be effective in alleviating age-related physiological decline in the lungs of C57BL/6 mice aged 8-10 months and bleomycin-induced pulmonary fibrosis in young mice aged 6-8 weeks.
Treating primary ACE with NMN can significantly improve cell senescence in vitro.
In addition, it has been found that NMN may alleviate osteoblast senescence and induce, guide, and promote bone healing in mice with osteoporosis.
Supplementation with NMN may attenuate senescent cell induction in growth plates, prevent osteoporosis in ovaries excision mouse models, and accelerate bone healing in osteoporotic mice, and NMN is expected to be a new and promising therapeutic candidate to enhance fracture healing in older adults.
NMN supplementation can improve mitochondrial dysfunction and restore cellular senescence in mesenchymal stem cells by activating the NAD+/Sirt3 pathway.
After NMN supplementation, intracellular NAD+ level, NAD+/NADH ratio and Sirt3 expression were significantly increased, and mitochondrial function was improved and senile mesenchymal stem cells were saved.
NAD+ is an essential compound present in all active cells and is involved in metabolism as a coenzyme. NAD+ is involved in many biological processes in the human body, but the body's NAD+ gradually declines with age.
Supplementing NAD+ with precursors is a scientifically recognized means of restoring healthy NAD+ levels. NAD+ molecules cannot penetrate the cell membrane into the cell, and direct supplementation of NAD+ is impractical, so the selection of NAD+ precursor NMN is effective.
Supplier Introduction: China glutathione supplier and NMN manufacturer GSHworld, the company mainly develops biotechnology and industrialization. As a global pioneer in enzymatic catalytic ATP regeneration technology, our company advocates green production and is committed to providing customers with better and more environmentally friendly products and services. Glutathione Manufacturer,NMN Factory,Citicoline Sodium supplier,China NMN manufacturers
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