NMN can improve the quality of oocytes in obese mice

Maternal obesity has adverse effects on both mother and baby

When an overweight woman goes to the obstetrical examination, she will often get the doctor's attention, and the obstetrical examination data will also be affixed with the sign of "high-risk maternal".

Obesity has many adverse effects on both the mother and the fetus.

The risk of pregnancy induced hypertension, pre eclampsia, and pregnancy induced diabetes is higher in pregnant women; The risk of fetal cleft lip and palate, anorectal atresia, congenital heart disease, neural tube defects, type 2 diabetes, cardiovascular disease, etc. will also increase.

NMN reduces the risk of maternal obesity

In July 2022, a study by Jilin University in China was published in the journal Cell Proliferation: Administration of Nicotinamide Mononucleotide improves oocyte quality of obese mice.

Oocytes are found in the ovaries, and after division, they eventually form an egg cell, which is often referred to as an egg.

The egg and sperm meet in the fallopian tube to form a fertilized egg, which eventually develops into a cute baby.

The team treated obese mice with NMN, a precursor of nicotinamide adenine dinucleotide (NAD+), and found:

DNA damage markers in healthy feeding (ND), high-fat feeding (HFD), and supplementing NMN (HFD+NMN) mice during high-fat feeding

The obese mice had more than twice as much damaged DNA in their oocytes as mice on a normal diet.

In obese mice treated with NMN, oocyte DNA damage was reduced by half, and NMN preserved the DNA integrity and oocyte quality of obese mice.

The integrity of the cellular protein skeleton is a key indicator of the quality and vitality of oocytes.

Research has found that the actin content in the outer membrane of oocytes in obese mice is only about half of that in normal diet mice.

Obese mice treated with NMN have more actin in the outer membrane of their oocytes than healthy women.

The offspring of obese mice have a lighter weight than healthy mice, while the offspring of obese mice treated with NMN have recovered to normal weight.

Tag: NMN

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