The effect of NMN on heart disease

According to the "2019 Global Health Assessment Report" released by the World Health Organization (WHO), in the 20 years from 2000 to 2019, ischemic heart disease was the number one cause of human death. And this cause of death not only continues to be the "number one killer" that threatens human health for many years, but also has an increasing trend year by year.

The research team of the First Affiliated Hospital of Nanjing Medical University in China reported in the core journal "Stem Cell Reviews and Reports" that vesicles secreted by stem cells (referred to as N-Vs) can improve myocardial infarction (heart attack) in rats after being treated with NMN The results of this experiment provide a new direction for the treatment of heart disease patients.

Research has shown that membrane-bound sacs called extracellular vesicles, secreted by stem cells (mesenchymal stem cells), are filled with potential therapeutic molecules. Like stem cells, these vesicles also have therapeutic properties. They have advantages over stem cells, including a lack of immune system rejection and tumor induction. When stem cell vesicles are subjected to various stimuli, their content will change, thereby affecting its biological effects.

Researchers surgically induced blockage of coronary arteries in rats, causing damage to heart tissue and simulating a heart attack. They then injected untreated and NMN-treated stem cell vesicles at the edge of the tissue injury in the rats. After four weeks, they found that the untreated vesicles increased the left ventricular ejection fraction -- the fraction of blood pumped by the heart. In addition, N-Vs further improved ejection fraction, suggesting enhanced functional repair of the heart.

Stem cell-derived vesicles (m-ev) increased ejection fraction after a heart attack (MI) with left ventricular ejection fraction (EF) % lower than normal (Sham), indicating improved cardiac function; when stem cells first Ejection fraction increased further when treated with NMN (n-ev).

The pumping action of the heart is most efficient when the blood flow regulated by the blood vessels is optimal. The researchers found that untreated stem cell vesicles increased the density of arterioles and capillaries in heart tissue from rats after a heart attack. In addition, N-Vs further increased arterial and capillary density. These findings suggest that NMN promotes vesicle-mediated angiogenesis, thereby increasing blood flow.

Myocardial infarction (MI) did not significantly increase arteriole (left) and capillary (right) formation compared with normal (Sham); whereas stem cell vesicles (m-ev) significantly increased vessel formation when stem cells first Blood vessel formation was further enhanced when regulated by NMN (n-ev).

In this regard, researchers from the First Affiliated Hospital of Nanjing Medical University in China said: "Our research shows that extracellular vesicles of stem cells can promote blood vessel formation, promote proliferation, inhibit apoptosis, reduce fibrosis and improve cardiac function. to improve heart function, and these functions were further enhanced after NMN treatment."

Tag: NMN

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