Triple Whitening Mechanism of Glutathione

Glutathione is a tripeptide naturally synthesized in human cells. It is composed of glutamic acid, cysteine and glycine. As an active tripeptide in the human body, it is ubiquitous in the human body and exists in almost every cell. middle. It can inhibit the formation of melanin from the front end, inhibit the activity of tyrosinase, and at the same time prevent the conversion of eumelanin into pheomelanin, blocking every link of melanin production.

It is well known that the tyrosinase inhibition rate is an important index to evaluate the whitening effect of some whitening agents, the higher the inhibition rate, the better the whitening effect. The common whitening agents chitosan, chitooligosaccharides and glutathione all have a good inhibitory effect on tyrosinase activity. How should one choose?

Studies have found that compared with chitosan, chitooligosaccharides and arbutin, glutathione has a better inhibitory effect, and the inhibition rate of tyrosinase can reach up to 85%.

Triple Whitening Mechanism of Glutathione:

1. Directly inhibit tyrosinase activity, sweep away a large number of oxidative free radicals, prevent free radicals from activating tyrosinase, and hydrolyze it into cysteine, and interfere with melanin precipitation.

2. Transfer melanin production from eumelanin to pheomelanin synthesis through the reaction between thiol and dopaquinone, indirectly regulating the switching mechanism from eumelanin to pheomelanin production. Because there are two types of melanin in human skin, eumelanin and pheomelanin, when the synthesis of eumelanin increases, the skin color becomes dark, and when the synthesis of pheomelanin increases, the skin color becomes white, tender and translucent.

3. Interfere with the cell transfer of tyrosinase to the forward melanosome, which is a prerequisite for melanin synthesis, and glutathione directly prevents melanin production from the source.

Glutathione has more than 100,000 literature studies. Because it participates in the oxidation-reduction process in the body, it combines with peroxides and free radicals, can scavenge active oxygen free radicals, prevent lipid peroxidation, and help metabolize peroxides and heavy metals at the same time. Prevent harmful substances from causing damage to cells and DNA, so it is widely used in medicine, food and cosmetics and other fields.

Tag: Glutathione GSH

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