Sep 24, 2024 / Author: China Glutathione suppliers & NMN manufacturers
When it comes to "immortality", the story of the first Emperor of Qin and Xu Fu is still fresh in the memory of every Chinese people. In order to pursue immortality, the First Emperor of Qin ordered Xu Fu to rate "three thousand boys and girls" and "one hundred workers", carrying "five seeds", and crossed the sea by boat to seek immortal medicine.
Science has proved that "immortality" is impractical, but "agelessness", that is, anti-aging, is completely achievable. Subsequently, there are a variety of anti-aging equipment, cosmetics, health products, etc., on the market, but many of them are symptoms rather than root causes, and they cannot maintain long-term anti-aging effects.
In the 1950s, Walford conducted pioneering research in biological gerontology, and in 1969, in his Immunological Theory of Aging, he argued that a decline in immune function could cause normal aging.
Walford proposed the concept of "immunosenescence" for the first time, which started the academic research on immune senescence.
The common features of immune senescence and cellular senescence include decreased immune function and increased release of inflammatory factors, which is mainly manifested by decreased immune response to endogenous and exogenous antigens, resulting in decreased anti-tumor ability of individuals and the ability to clear senescent cells.
Anti-aging is to fight cell aging, while improving the body's immunity. A miracle nutrient, NMN, has been pushed to the anti-aging tide;
NMN, short for β-Nicotinamide Mononucleotide, is a naturally occurring bioactive nucleotide structurally composed of nicotinamide, ribose, and phosphate groups.
NMN is a precursor of NAD+. NAD+ is a naturally occurring substance in the human body, and NAD+ gradually decreases with age.
The decrease of NAD+ will damage the ability of cells to produce energy, and the body will appear degenerative symptoms, such as muscle degeneration, brain loss, deepening of pigment, hair loss, etc., which is in the traditional sense of "aging", supplement NMN can improve the level of NAD+, so as to achieve anti-aging and improve the health of the body.
We do not focus on the efficacy of NMN, let's take a look at the celebrities who are inextricably related to NMN, why they are "crazy" for NMN?
David A. Sinclair is an expert in the anti-aging field and was named one of Time magazine's "100 Most Influential People in the World" for his discovery of NMN's anti-aging effects.
In 2013, Professor David A. Sinclair found that as A direct metabolic precursor of NAD+, a key coenzyme in the human body, NMN can quickly compensate for the gradually decreasing NAD+ molecules in the body, thus effectively activating "longevity protein" and playing a role in delaying aging.
Professor David A. Sinclair takes NMN and maintains A scientific diet and exercise routine.
Professor David Sinclair, 53, is 20 years younger than his actual age, or 33 years, according to biological age measurements.
Professor Shin-ichiro Imai, MD, Kyoto University, Japan, is one of the leading researchers on NMN.
Professor Shin-ichiro Imai's research has shown that increasing NAD+ levels can delay aging and improve body immunity.
In June 2019, the Shin-ichiroImai research group published a study showing that by increasing the level of NMN synthesis in mice by injection, the average remaining life of elderly mice was extended from 2 months (equivalent to 6 years of human life) to 4.6 months (equivalent to 14 years of human life), which was more than twice increased. One of the mice even lived for more than 1,029 days (equivalent to more than 103 years in humans).
Professor Rafael de Cabo, a biologist at the National Institute on Aging in the United States, is one of the leading figures in the study of NMN.
Professor Rafael de Cabo's research has shown that NMN can enhance metabolism and slow aging.
Rafael de Cabo's team found that ingestion of NMN in elderly mice significantly increased their NAD+ levels and improved the function of multiple organs, such as reducing heart hypertrophy and liver fat accumulation, while also extending the lifespan of elderly mice.
These results suggest that NMN may have an important role in maintaining health and extending life.
Johan Auwerx is a professor of biochemistry at the Ecole Polytechnique Federale de Lausanne in Switzerland and one of the leading researchers on NMN.
Professor Johan Auwerx's research has shown that NMN can improve metabolism and slow down aging.
Studies have shown that NMN can significantly improve the exercise ability and metabolic function of elderly mice, and delay the aging of mice.
Another study by Professor Johan Auwerx has shown that NMN can regulate mitochondrial function and reduce the secretion of cytokines, thereby inhibiting inflammatory responses, which are related to cell aging and disease.
In 2017, Li said he "felt 20 years old again" after taking an NAD+ precursor supplement.
Li Ka-shing will sell this NAD+ precursor health care product in Watsons stores, and invited well-known actress Hui Yinghong to endorse.
According to the British "Guardian" reported that Madonna, Rihanna, Katy Perry, Rita Ora, Gwyneth Paltrow and other stars are keen on NAD+ precursor "intravenous therapy."
Jennifer Aniston, in an interview with the Los Angeles Times, said, "The amount of NAD+ in our bodies decreases as we age, and it's a fundamental component of the mitochondria in our cells, and when it decreases, our bodies wear out, our genes go down, and we age."
NMN has become a research hotspot in the scientific community. In a series of scientific studies, it has been found that NMN can directly enter the cell. While improving the level of NAD+, NMN will not affect the activity of other enzymes in the human body and interfere with normal physiological activities.
We also hope that NMN will enter the public eye through a series of scientific proofs and star power.
As an important raw material for intracellular DNA repair, NMN can improve the concentration level of NAD+, restore the energy level and gene repair ability of cells to a young state, and realize the wish of anti-aging and "agelessness".
1. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging
2. Cell Metab. 2019 Aug 6;30(2):329-342.e5. doi: 10.1016/j.cmet.2019.05.015. Epub 2019 Jun 13. Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice
3. Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner doi: https://doi.org/10.1101/2024.06.21.599604
4. NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
Supplier Introduction: China glutathione supplier and NMN manufacturer GSHworld, the company mainly develops biotechnology and industrialization. As a global pioneer in enzymatic catalytic ATP regeneration technology, our company advocates green production and is committed to providing customers with better and more environmentally friendly products and services. Glutathione Manufacturer,NMN Factory,Citicoline Sodium supplier,China NMN manufacturers
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