Summary of human clinical studies of NMN

NAD+ is an important coenzyme responsible for cellular energy metabolism and DNA repair. Previous animal studies have demonstrated that NAD+ levels can be increased by supplementing NAD+ precursor NMN, thereby alleviating aging-related diseases. In recent years, there have been more and more human experiments on NMN, and the safety and effectiveness of NMN have gradually been confirmed in research. The following is a summary of the currently known human experiments on NMN.

Summary of Human Clinical Trial Results

Detailed information on human clinical trials

14- "Geriatrics" human clinical research: the greater the dose of NMN supplementation, the higher the level of NAD +

Date: December 2022

Scale: 80 subjects (age 40-65)

Time: 60 days

Dosage: 300mg, 600mg or 900mg NMN orally once a day

result:

1) The level of NAD+ gradually increases with the dose of NMN supplementation;[14]

2) Even supplementing high doses of NMN (900mg) is safe and reliable; [14]

3) Supplementing NMN can improve the physical function and health status of middle-aged and elderly people, such as increasing the pace; [14]

13- "International Geriatrics and Gerontology": Supplementing NMN can reduce the rate of retinopathy

Date: November 2022

Time: 24 weeks

Dosage: 250mg NMN daily

result:

1) It is safe and reliable for male diabetic patients over 65 years old to take 250 mg of NMN orally every day for 24 consecutive weeks; [13]

2) Supplementing NMN can increase the central retinal thickness of the subjects to reduce the rate of retinopathy; [13]

3) The health status of the subjects has been significantly improved [13]

12-Significantly reduce triglyceride levels and is safe and reliable, the first human clinical release of intravenous injection of NMN

Date: September 2022

Size: 10 subjects (average age 43.4 years)

time 1 day

Dosage: 300mg NMN intravenously

result:

1) The NAD+ level in the subject's blood increased by 20%; [12]

2) The level of triglycerides in the blood of the subjects was reduced by 75%; [12]

3) The blood test indicators and metabolic levels of vital organs of the subjects were within the normal range, and no adverse reactions occurred. [12]

11- Long-term daily oral administration of more than 1000mg of NMN has been confirmed to be safe, and "Scientific Report" released the latest human clinical results

Date: August 2022

Scale: 31 subjects (age 20-65)

Time: 4 weeks

Dosage: 1250mg NMN orally once a day

result:

After a healthy adult took 1250mg NMN orally once a day for 4 consecutive weeks, all the physical indicators were within the normal range, and no adverse reactions occurred. [11]

10-Japanese clinical trials: long-term supplementation of NMN can increase the elasticity of arterial vessels

Date: July 2022

Scale: 36 subjects (aged 40-59)

Time: 12 weeks

Dosage: 250mg NMN daily

result:

1) Supplementing 250 mg of NMN per day for adults for 12 consecutive weeks is safe and effective, with no adverse reactions; [10]

2) The NAD + metabolism level of the subject is significantly increased; [10]

3) The subject's pulse wave velocity decreases, and the arterial vessel elasticity increases. [10]

9-Japanese scientific research team: Supplementing NMN can delay female physiological aging

Date: June 2022

Size: 17 subjects (age 55)

Time: 8 weeks

Dosage: 300mg NMN daily

result:

1) The glucose metabolism in the subject is improved, and the risk of cardiovascular disease is reduced; [9]

2) The secretion of female hormones in the subjects increased, and the quality of skin and sleep improved; [9]

3) Subjects supplemented with 300mg NMN daily for 8 consecutive weeks without any adverse reactions; [9]

8- Long-term NMN supplementation can increase NAD+ levels in the elderly and enhance muscle strength

Date: May 2022

Size: 42 subjects (age 65 and over)

Time: 12 weeks

Dosage: 250mg NMN daily

result:

1) The NAD+ level in the subject increased by about 3 times; [8]

2) The gait speed of the subjects increased by 23%, and the grip strength increased by about 8%; [8]

3) It is safe and reliable to take 250mg NMN orally every day for 12 consecutive weeks. [8]

7- Supplementing NMN can significantly improve exercise ability and health status, "Frontiers of Aging" released the latest results of human clinical trials

Date: May 2022

Scale: 66 subjects (aged 40-65)

Time: 60 days

Dosage: 300mg NMN daily

result:

1) On the 30th day of the test, the NAD+/NADH level in the blood of the subjects increased by 11.3%; on the 60th day, the NAD+/NADH level in the blood of the subjects increased by 38%;[7]

2) On the 30th day of the test, the subjects' walking endurance increased by 4.3%; on the 60th day, the subjects' walking endurance increased by 6.5%; [7]

3) The subject's SF-36 score (health questionnaire developed by the Boston Institute of Health in the United States) increased by 6.5%; [7]

4) Supplementing 300mg NMN daily for 60 consecutive days is safe and reliable. [7]

6- Supplementing NMN can enhance insulin sensitivity, "Science" publishes the results of human clinical trials

Date: April 2022

Size: 25 subjects (age 55-75)

Time: 10 weeks

Dosage: 250mg NMN daily

result:

1) The muscle insulin sensitivity of the subjects increased by about 25%; [6]

2) The number of myoblasts in the subjects' skeletal muscles increased, and the regenerative capacity of skeletal muscles improved; [6]

3) The level of NAD+ was significantly increased by about 30%, and no adverse reactions were seen. [6]

5-Fuji Mountain University, Japan: Supplementing NMN can enhance skeletal muscle mass and reduce fat content

Date: April 2022

Scale: 30 subjects (age 20-65)

Time: 12 weeks

result:

1) Daily oral administration of 250 mg NMN for 12 consecutive weeks is safe and reliable, with no adverse reactions; [5]

2) The level of NAD+ and its related metabolites in the subject's blood is significantly increased; [5]

3) The body fat content of the subjects was reduced by about 8%, and the skeletal muscle mass was increased by about 10%. [5]

4- Supplementing NMN can greatly improve sleep quality and exercise capacity, Japan announced the latest results of human clinical trials

Date: February 2022

Size: 108 subjects (age 65 and over)

Time: 12 weeks

Dosage: 250mg NMN daily

result:

1) The sleep time of the subject is shortened, the sleep time is significantly prolonged, and the overall sleep quality of the subject is improved; [4]

2) The state of daytime fatigue and drowsiness is reduced, and the concentration of the subjects is significantly improved; [4]

3) The physical functions of the subjects were improved, such as increased grip strength and increased walking speed. [4]

3-The latest human research from Harvard University: MIB-626 can significantly increase the level of NAD+

Date: February 2022

Scale: 32 subjects (age 55-80)

Time: 14 days

Dosage: 1000mg or 2000mg MIB-626 per day (mixture with NMN as the main ingredient)

result:

1) It is safe and reliable to take 1000/2000mg MIB-626 daily, and the blood sugar, insulin, fat and uric acid levels of the subjects were all within the normal range, and no adverse reactions were seen; [3]

2) The NAD+ level in the subject increased by 2-3 times. [3]

2-Significantly improve exercise efficiency and cardiopulmonary function, China announced the first NMN human clinical research results

Date: July 2021

Scale: 48 subjects (age 27-50)

Time: 6 weeks

result:

1) All physical indicators of all subjects were within the normal range, and no adverse reactions were seen; [2]

2) Subjects taking 600mg or 1200mg of NMN per day had increased oxygen consumption during exercise; [2]

3) During exercise, the aerobic capacity of skeletal muscle increases with the increase of NMN dose. [2]

1- Japan's Keio University announced the first clinical results of NMN: the safety of a single oral administration was confirmed

Date: February 2020

Scale: 10 subjects (age 40-60)

Time: 5 hours

Dosage: single oral administration of 100mg, 250mg and 500mg NMN

result:

The subjects did not experience skin flushing or gastrointestinal adverse reactions, and their heart rate, blood pressure, and body temperature and other indicators were within the normal range. [1]

Tag: NMN

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