NMN can effectively improve the gut microbiota dysbiosis caused by sleep deprivation

With the increase of work pressure and diversification of entertainment in modern society, sleep deprivation (SD) is becoming more frequent and common.

Simply put, sleep deprivation (SD) refers to a situation in which an individual's sleep time is significantly reduced or completely absent within a certain period of time. For example, while adults should generally be getting 7-9 hours of sleep per night, getting less than 6 hours might be considered sleep deprived.

Sleep deprivation can have negative effects on body and brain health, including:
Decreased memory and concentration: Long-term sleep deprivation can affect the brain's learning and memory functions and make it difficult to concentrate.

Mood lability: Sleep deprivation may lead to mood lability, irritability, and anxiety.

Decreased immunity: Chronic sleep deprivation may lead to a compromised immune system, making a person more likely to get sick.
Physical health issues: Sleep deprivation has been linked to many physical health issues, such as high blood pressure, diabetes, and obesity.

There is also a strong link between sleep deprivation and gastrointestinal disorders. Clinical studies have shown that sleep disturbances contribute to the risk of inflammatory bowel disease infections, and worse, sleep deprivation can cause various detrimental effects on gut health, such as impaired gastric mucosal integrity, disturbed gut microbiota and microbiota Metabolic imbalance etc.

Moreover, dysbiosis of the gut microbiota and damage to the intestinal mucosa in turn lead to disturbances in circadian rhythms, lipid absorption and storage, increasing the risk of metabolic diseases including type 2 diabetes, non-alcoholic fatty liver disease, and obesity .
Studies have found that NMN helps to regulate the intestinal microbiota in many ways (including increasing the abundance of beneficial bacteria and reducing the abundance of harmful bacteria), and has a protective effect on the intestinal mucosa. Oral administration of NMN can improve the gut microbiota caused by sleep deprivation (SD). Microbiota dysbiosis restores colonization resistance (CR). Since the intestinal flora is not only related to the health of the gastrointestinal tract, but also affects factors closely related to human health and aging, such as circadian rhythm, immunity, metabolism, and nervous system function, this also proves the anti-aging effect of NMN from another perspective .

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