Supplementing NMN in Elderly Women May Improve Follicle Quality And Delay Reproductive Aging

The researchers found that supplementing NAD+ (nicotinamide adenine dinucleotide) precursor NMN (beta Nicotinamide Mononucleotide) can significantly improve the quality of aging oocytes, reduce the number of follicle ruptures, and enhance the fertilization ability of oocytes. The findings were published in the journal Cell Reports.

NAD+ is an important coenzyme in the human body and participates in most of the energy metabolism in cells. Previous studies have shown that the level of NAD+ in the body decreases with age and is associated with various diseases caused by aging. Therefore, increasing NAD+ levels may be an effective way to delay aging. NMN is the immediate precursor of NAD+, supplementing NMN can effectively increase the level of NAD+. In this study, the researchers verified whether the aging of reproductive function could be delayed by NMN supplementation.

The researchers divided young mice and old mice into two groups. The young mice and old mice in the control group were injected with PBS (phosphate buffer saline), and the experimental group was injected with NMN (200 mg/kg) for a total of 10 days. And on the 8th day and the 10th day, hormone ovulation induction was injected respectively. It was found that after NMN supplementation, the NAD+ content in oocytes of aged mice was significantly increased, the number of oocytes in aged mice was significantly increased, and the morphological defects of oocytes were correspondingly improved. Studies have demonstrated that NMN supplementation can significantly improve the quality of aging oocytes.

At the same time, the researchers found that compared with young mice, the number of follicles excreted in aged mice was significantly reduced, and the percentage of ruptured follicles was significantly increased; after NMN supplementation, the percentage of ruptured follicles in aged mice was significantly reduced and returned to The number of follicles released was also significantly increased at the same level as in young mice. Studies have shown that NMN supplementation can significantly reduce the number of ruptured follicles in aged mice.

Comparison chart of ovulation number and follicle rupture degree in young mice, aged mice and aged mice supplemented with NMN

The researchers then explored whether NMN could improve the fertility of aging oocytes. It was found that NMN supplementation can significantly increase the number of fertilized eggs, and the fertilized eggs divide normally and finally form a blastocyst structure. The researchers also found that NMN also increased the rate of blastocyst formation, further promoting subsequent embryonic development.

Finally, the researchers explored the mechanism by which NMN can restore the vitality of aging oocytes, and found that supplementing NMN can effectively reduce the accumulation of reactive oxygen species, which can cause DNA damage and lead to oocyte death, while supplementing NMN has a positive effect on aging oocytes. Can repair DNA damage, thereby inhibiting oocyte death.

The authors of the study believe that "supplementing NMN may be a potentially feasible method to improve the quality of egg cells in older women, and help to improve the fertility of older women." At the same time, assisted reproductive technologies such as IVF can also be considered to supplement NMN to improve the survival rate of oocytes cultured in vitro.

Tag: NMN

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