Coenzyme Q10 Regulates Lipids

Coenzyme Q10 is a fat-soluble coenzyme, a natural component produced by human cells, a natural antioxidant and cell metabolism activator that exists in the human body, and its main function is to activate cellular respiration, drive cells to generate energy, and has anti-fatigue and antioxidant properties. , anti-aging, improve human immunity and anti-tumor and other health care functions.

Recently, a Meta-analysis published by researchers from the School of Public Health of Sun Yat-Sen University Shenzhen Campus suggested that coenzyme Q10 has a lipid-lowering effect. For adults, supplementing 400-500 mg per day can achieve the greatest cholesterol-lowering effect.

Previously, the research team also found that supplementing coenzyme Q10 can help control blood sugar, especially in patients with diabetes, supplementing 100-200 mg per day has the greatest benefit.

The Meta-analysis included 15 relevant randomized controlled studies with a total of 2794 subjects.

The results of the pooled analysis showed that coenzyme Q10 can significantly reduce total cholesterol (5.53 mg/dl), low-density lipoprotein cholesterol (3.03 mg/dl), triglycerides (9.06 mg/dl), and increase high-density lipoprotein. Cholesterol (increase by 0.83 mg/dl).

The dose-response analysis showed that there was a J-shaped relationship between the coenzyme Q10 supplementation dose and total cholesterol level, and the total cholesterol level was lowest when the daily coenzyme Q10 supplementation dose was 400-500 mg.

Current research shows that coenzyme Q10 has a wide range of biological effects, including antioxidant, maintenance of normal blood pressure and cholesterol levels, maintenance of normal cognitive function, improvement of insulin resistance, etc.

In 2020, a position paper on nutritional care support for heart failure published by the International Lipid Expert Group pointed out that supplementation of coenzyme Q10 (especially at a dose ≥ 200 mg/d) in patients with chronic heart failure, especially in the early stage of heart failure, may Helps reduce major adverse cardiac events and overall mortality.