Glutathione Whitening Anti-aging

Glutathione is widely distributed in animal, plant and microbial cells, among which glutathione is abundant in animal and human viscera, wheat germ, and yeast, and a small amount in vegetable tissues. As an important biologically active substance in the body, glutathione has physiological functions such as anti-aging, anti-oxidation, anti-allergy, reducing fatigue and preventing diabetes.

1. Antioxidant

The human body produces a large amount of free radicals every day, and environmental factors will also promote the production of free radicals in the human body. Excessive free radicals will oxidize normal substances in the human body, damage the cell structure, and promote the malignant transformation of cells.

The sulfhydryl group (-SH) of glutathione can be oxidized to -S-S- bond, thereby generating cross-linked disulfide bonds in protein molecules. Reversibility of reduction. Among the two configurations, the effect of the reduced form is greater, and the reduced form of glutathione can reduce the -S-S- bond in biological enzymes to -SH, thereby restoring or improving their activity.

Two molecules of GSH can be oxidized to one molecule of GSSG (oxidized glutathione) under the action of glutathione peroxidase GPX, and at the same time neutralize free radical H2O2 to form harmless water and oxygen molecules, thereby protecting cell membranes The structure and function are protected from interference and damage by peroxides. GSSG is reduced to GSH under the action of glutathione reductase, and at the same time, the hydrogen transfer body NADPH is oxidized to NADP+ (nicotinamide adenine dinucleoside phosphate), thus forming a redox cycle to avoid oxidative damage.

2. Anti-allergic

Zhao Xinling et al. studied the in vitro antiallergic activity of glutathione, mainly through hyaluronidase inhibition experiments.

The inhibition rate of glutathione to hyaluronidase increases with the increase of concentration. When the concentration is lower than 3 mg/ml, the inhibition rate of hyaluronidase has a linear relationship with the concentration of glutathione, and With the increase of glutathione concentration, the inhibition rate of hyaluronidase changed greatly; when the concentration was higher than 3 mg/ml, the inhibition rate increased slowly with the increase of glutathione concentration. Glutathione has strong anti-allergic activity.

3. Whitening

In 2012, the effect of oral glutathione (500 mg daily for 4 weeks) on skin melanin was studied. 60 volunteers were divided into two groups, the experimental group and the placebo group, and six parts of the skin were tested (left and right face, left and right forearm, left and right inner wall 10 cm from the armpit).

The results showed that the melanin values of the six test sites in the glutathione experimental group decreased significantly. Glutathione has a certain whitening effect on melanin caused by ultraviolet rays.

4. Anti-aging

In 2017, the anti-aging effects of glutathione were studied in a randomized double-blind experiment in which healthy female volunteers were randomly divided into three groups: oral GSH (250 mg/d), GSSG (250 mg/d) or placebo 12 weeks.

The results found that both GSH and GSSG could improve skin condition. Compared with the placebo group, all subjects had less dark spots caused by ultraviolet rays, and some subjects had reduced skin wrinkles and increased elasticity after glutathione supplementation.