01
Jun
NMN is widely found in natural foods and is found in vegetables, fungi, meat, and shrimp (see Table 1). Ummarino et al. also found that NMN exists in human milk and donkey milk through a new enzyme coupling technology, and the content in human milk is higher. The processing characteristics study...
31
May
Nicotinamide mononucleotide (NMN) has a variety of biological functions, which are useful for heart and brain diseases, senile degenerative diseases, neurodegenerative diseases, and anti-aging. The skeletal muscle treated with NMN has significantly preventive effect on the transcriptional...
27
May
Cholesterol metabolism homeostasis plays an important role in maintaining normal life activities, and blood cholesterol levels that are too low or too high will have adverse effects on the human body. Hypercholesterolemia is caused by high levels of LDLC in cholesterol metabolism disorders, and...
26
May
Tumor has become a very important medical research problem due to its complex mechanism. Cancer stem cells are an important subset of tumor cells, which play an important role in the occurrence and development of many tumors, and are closely related to the growth characteristics and...
25
May
In recent years, the role of glutathione in regulating stem cell differentiation by participating in the energy metabolism of stem cells has become increasingly clear. Hypoxic environment can protect stem cells from the production and accumulation of harmful reactive oxygen species. Stem cells...
23
May
Glutathione is a tripeptide compound found in all living cells and is a combination of glutamic acid, cystine and glycine. Glutathione is an important intermediate substance in biological metabolism, mainly in defense of DNA damage, especially in wheat germ and yeast. Glutathione has two forms,...
20
May
In addition to the damage protection of stem cells, reduced glutathione is also closely related to the immune regulation function of stem cells. For example, ALLAMEH et al. found that when bone marrow mesenchymal stem cells differentiate into hepatocytes, the depletion of reduced glutathione can...
19
May
Glutathione can prevent the damage of stem cells and promote the self-renewal of stem cells as a potential activation signal in the early stage of apoptosis. Reduced glutathione can affect DNA synthesis, transcription and repair by regulating redox signals. Depletion of prototypical glutathione...
18
May
The redox state of stem cells is jointly determined by reactive oxygen species and the cellular antioxidant system. When the production of reactive oxygen species exceeds the processing capacity of the cellular antioxidant system composed of oxidoreductases and other antioxidant molecules, stem...
17
May
In recent years, there have been more and more human clinical trials for NMN, and many feedbacks worthy of reference have been obtained. Recently, scientists conducted a randomized, parallel, double-blind, placebo-controlled human clinical trial of NMN. Among the middle-aged and elderly (40-65...
16
May
Stroke is an acute cerebrovascular disease caused by cerebral blood circulation disorder, which has high mortality and morbidity, and seriously threatens human health. Studies have found that NMN can protect cranial nerves and promote blood vessel and nerve regeneration by activating the...
12
May
The causes of visual impairment are complex and varied, but photoreceptor death is the end point of many blinding diseases. Photoreceptors constitute an important part of the neurosensory retina, one of the most metabolically active tissues in the body. Lin et al. showed that multiple mouse...
12
May
With the accelerating trend of social aging, the incidence of Alzheimer's disease (AD) is increasing year by year. The disease is a central nervous system disease characterized by cognitive dysfunction and memory impairment. Abnormal mitochondrial structure and function is one of the...
10
May
Another serious threat to health related to aging is cardiovascular disease (Cardiovascular diseases, CVD), which has the characteristics of high morbidity, high disability rate, and harm to a wide range of people. These diseases are mainly due to the imbalance of the oxidative system and the...
09
May
Obesity is closely related to the development of type 2 diabetes. Type 2 diabetes is mainly due to the failure of pancreatic islets to produce enough insulin and the decreased sensitivity of glucose-metabolizing tissues to insulin. Obesity leads to adipose tissue dysfunction, increased release...
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