Feb 10, 2025 / Author: China Glutathione suppliers & NMN manufacturers
Since ancient times, many people have been seeking "longevity" through various methods, and today people are still pursuing the path of delaying aging.
So, once NMN was introduced, coupled with media coverage, it quickly became known to more and more people and was warmly sought after.
The exploration of NMN in the scientific research field has not stopped, and multiple academic papers have been published in authoritative academic journals such as Cell, Nature, and Science.
With the continuous deepening of research, the anti-aging function of NMN is constantly being discovered, and more studies are underway.
So what are the benefits of NMN that scientific research has discovered?
NAD+(nicotinamide adenine dinucleotide) is an important substance that maintains the functioning of the body. It exists in all cells and participates in thousands of physiological processes in the body.
As a participant in metabolism and an auxiliary molecule of proteins that regulate other biological activities, its role is mainly reflected in providing energy to cells, enhancing immunity, accelerating tissue repair and regeneration, thereby maintaining a healthy state of the human body and delaying aging.
In 2013, a research team led by Professor David Sinclair from Harvard Medical School demonstrated through experiments that after oral administration of NMN for one week, the NAD+levels in 22 month old mice increased, and key biochemical indicators related to mitochondrial homeostasis and muscle function were restored to the state of 6-month-old young mice.
The research results were published in the journal Cell.
Sirtuins are a family of NAD+- dependent deacetylase proteins, including Sirtuin1 to Sirtuin7 (SIRT1-7).
Research over the past 20 years has found that Sirtuins play a major regulatory role in almost all cellular functions.
Sirtuins affect physiological processes such as inflammation, cell growth, circadian rhythm, energy metabolism, neuronal function, and stress resistance.
In 2019, Professor KaneA E and colleagues from the Department of Genetics at Harvard Medical School discovered that NMN, as an important precursor for NAD+synthesis in organisms, exerts many beneficial effects (such as improving metabolism and protecting cardiovascular health) by activating Sirtuins after increasing intracellular NAD+levels.
In 2019, Dr. dePicciotto NE and colleagues from the Department of Integrative Physiology at the University of Colorado Boulder found that intraperitoneal injection of NMN can increase the activity of Sirtuin1 in mouse arteries and reverse age-related arterial dysfunction and oxidative stress. In addition to activating Sirtuin1, NMN can also reduce oxidative stress and improve vascular function in elderly mice through other pathways. For example, NMN can also affect the activity of Sirtuin3 in mitochondria, reduce oxidative stress, and enhance physiological function.
In addition to affecting Sirtuins activity, the level of NAD+in the body is also an important substrate for the action of DNA repair enzymes PARPs (poly (adenosine diphosphate ribose polymerase)).
In 2017, a research team led by Professor David Sinclair from Harvard Medical School discovered the mechanism by which NAD+repairs DNA damage.
As the NAD+level decreases with age, DNA repair enzyme PARP1 is increasingly combined by DBC1 (breast cancer deletion factor 1) to form PARP1-DBC1 complex, which will prevent PARP1 from repairing damaged DNA.
Increasing NAD+levels can interfere with the formation of PARP1-DCC1 complex, thereby restoring the DNA repair activity of PARP1. After oral administration of NMN to elderly mice exposed to radiation for one week, a reduction in DNA damage was observed.
The research findings were published in the journal Science.
Metabolism is the collection of chemical reactions that sustain life within an organism, and is the general term for the chemical reactions that sustain life in an organism.
These reactions enable organisms to grow and reproduce, maintain their structure, and respond to the environment.
Metabolism is the continuous process of exchanging matter and energy in living organisms. Once the exchange of matter and energy stops, the life of the organism will come to an end.
In 2019, a study by Professor Nina Klimova and colleagues at the University of Maryland School of Medicine found that intraperitoneal injection of NMN significantly increased mitochondrial NAD+levels in the hippocampus of experimental rats, and elevated the energy molecule ATP levels in brain tissue, thereby improving the body's biological energy metabolism.
In addition, NMN can increase the activity of antioxidant enzymes in mitochondria and reduce the production of reactive oxygen species.
In December 2019, a study published in the Journal of Affective Disorders showed that:
NMN can improve the condition of cortisol induced depression in mice.
In this experiment, NMN improved energy metabolism and mitochondrial function in depressed mice, and corrected their negative behavior.
In 2020, Dr. Jie Xiaoxian and his team from Zhejiang University of Technology found that oral administration of NMN to depressed mice increased NAD+levels, activated Sirtuin3, improved mitochondrial energy metabolism in the hippocampus and liver cells of mice, and thus alleviated depressive symptoms.
Blood vessels are the "conduits for blood circulation" and are essential tissues for carrying oxygen and nutrients, processing carbon dioxide and metabolites, regulating body temperature, and other vital activities.
As people age, blood vessels gradually lose their flexibility, become harder, thicker, and narrower, leading to "arteriosclerosis".
In 2018, a research team led by Professor David Sinclair from Harvard Medical School found that 18 month old mice orally administered NMN for 2 months restored the number and density of capillaries to the levels of young mice, increased muscle perfusion and dissolved oxygen content at rest, and improved exercise endurance by 58% -80%. After exercise, lactate levels in the blood decreased.
The research findings were published in the journal Cell.
In 2016, Dr. dePicciotto N E and colleagues from the Department of Integrative Physiology at the University of Colorado Boulder found that oral administration of NMN can restore endothelial dependent dilation (EDD) and nitric oxide mediated EDD in aged mice, reduce aortic pulse conduction rate (aPWV), decrease nitrotyrosine, reverse collagen I, increase elastin, and restore vascular SIRT1 activity, thereby maintaining vascular elasticity and maintaining vascular health.
Weight can reflect a person's health status. Weight not only affects quality of life and health, but also becomes a trigger for other chronic diseases.
Weight management refers to regulating the balance of energy and substance metabolism in the body through proper nutrition and moderate exercise.
Both low and high body weight can increase the risk of chronic diseases.
In 2017, Margaret J. from the University of New South Wales School of Medicine Professor Morris led a team to conduct a series of studies on the weight management role of NMN, and found that for genetically obese mice, both NMN and exercise can reduce obesity and improve glucose tolerance and mitochondrial function.
However, NMN appears to have a stronger effect on hepatic fat breakdown metabolism (Hadh) and synthesis metabolism (Fasn) than exercise, possibly due to injection of NMN increasing NAD+levels in the body, thereby activating Sirtuins protein and increasing hepatic fat breakdown metabolism and synthesis metabolism.
The health of the heart is crucial to the survival of the human body, and maintaining heart function is essential.
In 2014, Dr. Yamamoto et al. from the New Jersey Medical School found that intraperitoneal injection of NMN in mice significantly increased the level of NAD+in the heart and prevented a decrease in NAD+during ischemia.
NMN protects the heart from ischemia/reperfusion injury.
In 2017, research by Dr. Rongli Zhang and others from Case Western Reserve University School of Medicine showed that short-term intraperitoneal injection of NMN successfully protected mice from heart failure caused by pressure overload.
This is because NMN protects the ultrastructure of mitochondria, reduces reactive oxygen species levels, and prevents cardiac cell death.
Neurovascular dysfunction can cause early vascular and neurodegenerative cognitive impairment.
Risk factors such as diabetes, middle-aged hypertension, middle-aged obesity, lack of physical activity and smoking are all related to vascular dementia and Alzheimer's disease. Maintaining neurovascular function is of great significance in preventing neurodegenerative diseases.
In 2019, Dr. Tarantini et al. from the University of Oklahoma Health Sciences Center found that intraperitoneal injection of NMN has a significant protective effect on the cerebral microvasculature of aging mice. NMN can alleviate oxidative stress in the cerebral microvascular endothelium, improve endothelial function, and rescue the neurovascular coupling (NVC) response in the cortex of aging mice, which may help improve cortical function.
In 2020, a study by Dr. TamasKiss and colleagues at the University of Oklahoma Health Science Center also found that restoring cellular NAD+levels in aging mice through intraperitoneal injection of NMN can rescue neurovascular function, increase cerebral blood flow, and improve cognitive ability.
Insulin resistance (IR) refers to a state in which the target organ of insulin is less sensitive to insulin action, meaning that the normal dose of insulin produces less than the normal biological effect.
Insulin sensitivity refers to the degree of insulin resistance.
The lower the insulin sensitivity, the less effective the unit insulin is, and the lower the degree of sugar breakdown.
One of the reasons for type 2 diabetes is that insulin secretion is low; The other is low insulin sensitivity.
In 2016, Kelly L. from the University of Washington School of Medicine Dr. Stromsdorfer et al. found that the decrease in NAD+levels in adipose tissue of obese and elderly mice is associated with severe multi organ insulin resistance.
Adding NMN to the drinking water of mice with insulin resistance caused by specific enzyme inactivation can reverse insulin resistance and reduce the concentration of free fatty acids in plasma.
In 2012, Dr. YoshinoJ, Department of Developmental Biology, Washington University School of Medicine, and other researchers found that intraperitoneal injection of NMN improved glucose tolerance and lipid distribution in type 2 diabetes mice by increasing the level of NAD+, enhanced insulin sensitivity in the liver, and restored the expression of genes related to oxidative stress, inflammatory response and circadian rhythm.
Aging is the result of accumulated factors such as stress and strain, injury and infection, weakened immune response, nutritional disorders, metabolic disorders, etc.
The accumulation of aging factors can be reduced through nutritional supplements or developing good lifestyle habits, thereby delaying aging.
In 2016, a research team led by Professor Shinichiro Imai at the University of Washington School of Medicine conducted a long-term experiment of oral administration of NMN in mice.
Compared with normal aging mice that did not take NMN orally for 12 months, orally administered NMN quickly converted into NAD+in tissues and effectively eliminated various physiological declines related to aging:
Prevent aging related weight gain, improve metabolism, increase physical strength, improve insulin sensitivity and plasma fat levels, improve vision, enhance immune function, prevent bone density decline, and more.
Moreover, NMN has no toxicity or side effects. On April 20, 2020, Robert Huizenga, a medical PhD from Harvard University, and Cedars Sinai Medical Center jointly released a report:
A 55 year old patient with severe COVID-19 (dyspnea, body temperature 39.4 ℃) received oral NMN cocktail therapy for 12 hours, his overall immune level improved (the absolute lymphocyte count increased by 85%), and the virus test turned negative 10 days after NMN combined treatment.
Long term alcohol consumption is a significant cause of liver disease worldwide.
Biochemical mechanisms including oxidative stress, inflammation and metabolic disorders, and disruption of NAD+/NADH are associated with the occurrence and development of alcoholic liver disease (ALD).
The decrease in liver NAD+levels mediated by ethanol (i.e. alcohol) is considered one of the inhibitory factors for ethanol induced steatosis, oxidative stress, steatohepatitis, insulin resistance, and gluconeogenesis.
In 2019, Mohammed A. Assiri et al. found that NMN can increase the liver NAD+level in experimental mice and alter the expression of 25% of genes regulated by ethanol metabolism, which is of great significance for the treatment of alcoholic fatty liver.
The decline in oocyte quality is a limiting factor for female fertility.
This decline in oocyte quality occurs with a rapid decrease in NAD+levels as age increases.
A study published in CellReport in February 2020 found that the use of NAD+precursor NMN can restore the quality and vitality of oocytes in aging animals, leading to fertility recovery.
The benefits of NMN also extend to developing embryos, reversing the adverse effects of maternal age on embryo development.
These findings suggest that the restoration of NAD+levels helps to enhance the fertility of female mammals.
Supplier Introduction: China glutathione supplier and NMN manufacturer GSHworld, the company mainly develops biotechnology and industrialization. As a global pioneer in enzymatic catalytic ATP regeneration technology, our company advocates green production and is committed to providing customers with better and more environmentally friendly products and services. Glutathione Manufacturer,NMN Factory,Citicoline Sodium supplier,China NMN manufacturers
+86-755-23577295
+86 18718790084
Room 832, Building 12, Shenzhen Bay Science and Technology Ecological Park, Yuehai Street, Nanshan District, Shenzhen China
English
NMN-BIO
Chinese
