What happens to insomnia patients after taking NMN?

Sleep is an important physiological process in the human body and is essential for maintaining physical and mental health.

With the acceleration of the pace of modern life and the increase of pressure, more and more people are facing sleep problems. In recent years, a number of NMN studies have shown that it has the effect of improving sleep.

Sleep is divided into non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. NREM sleep is divided into three stages, namely light sleep, moderate sleep and deep sleep.

During the deep sleep phase, the body is fully rested and refreshed, and the immune system is also strengthened. REM sleep is associated with dreams and memory consolidation.

The regulation of sleep involves multiple nervous system and physiological processes.

The suprachiasmatic nucleus (SCN) of the hypothalamus is the body's biological clock center, which regulates the sleep-wake cycle by secreting hormones such as melatonin.

Neurotransmitters in the nervous system such as serotonin, dopamine and gamma-aminobutyric acid (GABA) are also involved in the regulation of sleep.

There are three mechanisms by which NMN improves sleep:

(1) Regulate the biological clock

Studies have shown that NMN can influence the expression of clock genes by regulating the activity of SIRT1 proteins, thereby regulating the sleep-wake cycle.

The SIRT1 protein can bind to the promoter region of the clock gene and inhibit its expression, thereby prolonging sleep time.

NMN can also promote the secretion of melatonin, which further regulates sleep.

(2) Enhance neurotransmitter function

1. GABA: GABA is an important inhibitory neurotransmitter, which can inhibit the excitability of neurons and promote sleep.

Studies have found that NMN can increase the amount of GABA in the brain, thereby enhancing its inhibitory effect and promoting sleep.

2. Serotonin: Serotonin is a neurotransmitter that regulates physiological processes such as mood, appetite, and sleep.

NMN can promote the synthesis and release of serotonin, thereby improving sleep quality.

(3) Antioxidant and anti-inflammatory effects

Lack of sleep can lead to increased oxidative stress and inflammation, which can affect sleep quality.

NMN has antioxidant and anti-inflammatory effects, which can reduce the production of free radicals and reduce the levels of inflammatory factors, thereby improving sleep quality.

Clinical study of NMN to improve sleep

Several studies have shown that feeding NMN to mice can significantly extend their sleep time and improve sleep quality.

One study found that feeding NMN to elderly mice improved their sleep-wake cycles and increased the length of deep sleep. Similar results were observed in experiments with rats.

Injecting rats with NMN can increase the amount of GABA in their brains, enhancing its inhibitory effect and promoting sleep.

Some small human clinical trials have also shown the potential role of NMN in improving sleep.

A study in older adults found that taking NMN orally improved sleep quality and reduced the number of night-time awakenings.

Tag: NMN

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